Description

n-Tetradecanoyl-L-Proline is a high-purity, synthetic derivative of the amino acid L-proline, modified with a myristoyl (tetradecanoyl) chain. This structural modification enhances its lipophilicity, making it a valuable intermediate for advanced research and development in pharmaceutical chemistry and peptide synthesis. It is particularly sought after by R&D chemists and process development scientists working in the fields of drug discovery, prodrug design, and the development of novel bioactive compounds. The compound's specific stereochemistry and functional groups are critical for applications requiring precise molecular interactions.

Application

• Pharmaceutical Intermediate: A key building block in the synthesis of novel active pharmaceutical ingredients (APIs) and prodrugs, particularly those targeting enhanced bioavailability.
• Peptide Chemistry Research: Used in the development and study of modified peptides, where the lipophilic chain can influence membrane permeability and biological activity.
• Bioconjugation & Probe Development: Serves as a reagent for attaching lipid moieties to biomolecules, creating tools for biochemical and cellular studies.
• Cosmetic & Dermatological Actives: Investigated for use in the formulation of advanced skincare products, where peptide derivatives can support skin barrier function and delivery.
• Chemical Biology Tool: Employed in research to modulate protein-protein interactions or enzyme activity through targeted acylation.
• Reference Standard: Used as a certified reference material in analytical laboratories for method development and quality control of related substances.

Basic Information

Product Name	n-Tetradecanoyl-L-Proline
CAS No.	86282-96-4
Molecular Formula	C19H35NO3
Molecular Weight	325.49 g/mol
Synonyms	L-Proline, 1-(1-oxotetradecyl)-; Myristoyl-L-proline; 1-Myristoyl-L-proline; Tetradecanoylproline; (S)-1-(1-Oxotetradecyl)pyrrolidine-2-carboxylic Acid; N-Myristoyl-L-proline; N-Tetradecanoyl-L-proline; Proline, N-tetradecanoyl-, L-
EINECS	Contact for details

Quality Control

Every batch of n-Tetradecanoyl-L-Proline is manufactured under a strict quality management system and undergoes comprehensive analytical testing to ensure identity, purity, and consistency. Our standard quality commitment includes HPLC purity ≥98.0% and full characterization by spectroscopic methods (NMR, IR, MS). A detailed Certificate of Analysis (COA) is provided with each shipment, documenting all test results against established specifications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive). For long-term storage, consider desiccated conditions to maintain stability and prevent clumping or degradation.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥ 98.0%
Specific Rotation	Contact for details
Loss on Drying	≤ 1.0%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.