Description

(R,S)-1-Methyl-3-Nicotinoylpyrrolidone-D3 is a deuterated derivative of a nicotinoyl pyrrolidone compound, serving as a valuable isotopically labeled building block. Its core value lies in enabling advanced research and development in pharmacokinetics, metabolic studies, and analytical method development by providing an internal standard with minimal isotopic interference. This compound is essential for scientists and manufacturers in the pharmaceutical, agrochemical, and life science sectors who require high-fidelity tracers for mass spectrometry and NMR-based analyses.

Application

• Internal Standard for LC-MS/MS: Used as a stable, isotopically labeled reference standard in quantitative bioanalytical methods for drug and metabolite analysis.
• Metabolic Pathway Tracing: Employed in pharmacological and agrochemical research to study the absorption, distribution, metabolism, and excretion (ADME) of parent compounds.
• Deuterated Pharmaceutical Intermediate: Acts as a key synthon in the synthesis of deuterated drug candidates, which can offer improved metabolic stability and pharmacokinetic profiles.
• NMR Spectroscopy: Serves as a useful probe in nuclear magnetic resonance studies due to the distinct signal of deuterium atoms.
• Quality Control & Method Validation: Critical for ensuring accuracy and precision in analytical laboratories for regulatory compliance (e.g., FDA, EMA).

Basic Information

Product Name	(R,S)-1-Methyl-3-Nicotinoylpyrrolidone-D3
CAS No.	86270-95-3
Molecular Formula	C11H10D3NO2
Molecular Weight	194.25 g/mol (for deuterated form)
Synonyms	1-Methyl-3-(pyridine-3-carbonyl)pyrrolidin-2-one-d3; 3-(1-Methyl-2-oxopyrrolidin-3-yl)carbonylpyridine-d3; Nicotinoyl-1-methyl-2-pyrrolidone-d3; 1-Methyl-3-nicotinoylpyrrolidin-2-one-d3; Deuterated Cotinine analog precursor; Isotopically labeled pyrrolidone derivative; 86270-95-3; (Rac)-1-Methyl-3-nicotinoylpyrrolidone-D3
EINECS	Contact for details

Quality Control

Our (R,S)-1-Methyl-3-Nicotinoylpyrrolidone-D3 is produced under strict quality management systems. Each batch undergoes comprehensive analytical testing, including NMR and mass spectrometry for isotopic purity and chemical identity verification, and HPLC for chemical purity assessment. Certificates of Analysis (COA) detailing batch-specific results for purity, isotopic enrichment, and impurities are provided to ensure compliance with your research and development requirements.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at controlled room temperature (15-25°C). This material is hygroscopic (moisture-sensitive); therefore, containers must be kept tightly sealed in a dry environment to prevent degradation. For long-term storage, consider using desiccants.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (IR)	Conforms to structure
Identification (MS)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Isotopic Purity (D-content)	≥ 98 atom % D
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.