Description

α-Sarcin is a potent cytotoxic ribonuclease protein derived from the fungus *Aspergillus giganteus*, known for its specific cleavage of ribosomal RNA. This compound is a critical tool in biochemical and pharmacological research for studying protein synthesis inhibition and ribosome structure. It is primarily utilized by research institutions and pharmaceutical companies focused on oncology, virology, and the development of novel therapeutic agents.

Application

• Biochemical Research: Used as a specific ribonuclease to study ribosome inactivation, RNA-protein interactions, and the mechanisms of protein synthesis inhibition.
• Anticancer Studies: Investigated for its potential as a cytotoxic agent in oncology research, particularly in understanding and inducing apoptosis in cancer cells.
• Virology Research: Employed in studies exploring antiviral strategies, as certain ribosome-inactivating proteins can inhibit viral replication.
• Immunotoxin Development: Serves as a potent payload in the research and design of immunoconjugates and targeted therapies.
• Cell Biology: A tool for probing cellular processes and for creating cell-free systems in molecular biology experiments.
• Pharmaceutical Screening: Used in high-throughput assays to identify compounds that modulate ribosome function or protect against cytotoxic stress.

Basic Information

Product Name	α-Sarcin
CAS No.	86243-64-3
Molecular Formula	C~660H~1020N~170O~200S~5 (Approx.)
Molecular Weight	~17,000 Da
Synonyms	α-Sarcin; Aspergillus giganteus α-Sarcin; Ribonuclease α-Sarcin; Cytotoxin α-Sarcin; Sarcin; Antifungal Protein AFP; Gigantin; Restrictocin (related toxin); 28S rRNA-specific ribotoxin; Ribosome-inactivating protein (RIP)
EINECS	Contact for details

Quality Control

Our α-Sarcin is produced and handled under stringent conditions to ensure high purity and biological activity for research applications. Each batch is subjected to comprehensive analytical testing, including SDS-PAGE, HPLC for purity assessment, and activity assays to confirm specific ribonuclease function. A detailed Certificate of Analysis (COA) is provided with every shipment, documenting purity, potency, and endotoxin levels where applicable.

Storage

Preserve in a tightly closed container, protected from light. For long-term stability, store lyophilized powder at -20°C or below. Reconstituted solutions should be aliquoted and stored at -70°C to -80°C to prevent repeated freeze-thaw cycles. The product is hygroscopic (moisture-sensitive); ensure the container is sealed under anhydrous conditions after each use.

Specification

Item	Specification
Appearance	White to off-white lyophilized powder
Identification (HPLC/MS)	Conforms to standard
Purity (SDS-PAGE)	≥ 95%
Purity (RP-HPLC)	≥ 98.0%
Biological Activity	≥ 90% of reference standard
Endotoxin (LAL test)	< 1.0 EU/μg
Moisture Content (KF)	≤ 5.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.