Description

Substance P, Tyr(1)-Nle(11)- CAS NO 86227-34-1 is a synthetic, site-specifically modified analog of the endogenous neuropeptide Substance P. This engineered peptide is of significant value for research and development due to its enhanced stability and specific receptor interaction profile compared to the native sequence. It is primarily needed by pharmaceutical researchers, neuroscientists, and biochemical suppliers focused on neurokinin receptor studies, pain pathway analysis, and the development of novel therapeutic agents.

Application

• Neuroscientific Research: A critical tool for studying the role of Substance P and neurokinin-1 (NK1) receptors in pain signaling, inflammation, and emotional regulation.
• Drug Discovery & Development: Used as a reference standard or pharmacological probe in high-throughput screening (HTS) assays to identify and characterize new NK1 receptor antagonists or agonists.
• Biochemical Assays: Employed in receptor binding studies, cell-based functional assays (e.g., calcium flux, cAMP), and signal transduction pathway analysis.
• Academic & Institutional Research: Supports fundamental research in universities and institutes exploring the central and peripheral nervous system.
• Peptide Chemistry Studies: Serves as a model compound for investigating structure-activity relationships (SAR) due to its specific tyrosine and norleucine substitutions.
• Diagnostic Development: Potential use in the development of diagnostic kits or imaging agents targeting Substance P pathways.

Basic Information

Product Name	Substance P, Tyr(1)-Nle(11)-
CAS No.	86227-34-1
Molecular Formula	C68H103N19O16S
Molecular Weight	1442.7 g/mol
Synonyms	[Tyr1, Nle11]-Substance P; Tyr1-Norleucine11-Substance P; Substance P (1-11), Tyr(1)-Nle(11)-; H-Tyr-Pro-Lys-Pro-Gln-Gln-Phe-Phe-Gly-Leu-Nle-NH2; Neurokinin P analog; NK1 receptor ligand analog; Modified Substance P fragment
EINECS	Contact for details

Quality Control

Our Substance P, Tyr(1)-Nle(11)- is produced under controlled conditions and undergoes rigorous analytical testing to ensure high purity and batch-to-batch consistency, essential for reliable research outcomes. Quality is verified by multiple orthogonal methods including HPLC, MS, and amino acid analysis. A comprehensive Certificate of Analysis (COA) detailing purity, identity, and peptide content is provided with each batch to support your quality assurance protocols.

Storage

Preserve in a tightly closed container, protected from light. Store desiccated at -20°C or below for long-term stability. This product is hygroscopic (moisture-sensitive). Allow the vial to equilibrate to room temperature in a desiccator before opening to prevent condensation and hydrolysis. For short-term use, store at 2-8°C.

Specification

Item	Specification
Appearance	White to off-white lyophilized powder
Identification (HPLC)	Retention time corresponds to reference standard
Identification (MS)	Consistent with theoretical molecular weight
Purity (HPLC)	≥ 95% (Area % at 214 nm)
Peptide Content	≥ 80% (by amino acid analysis)
Single Impurity (HPLC)	≤ 1.0%
Water Content (KF)	≤ 5.0%
Acetate Content (HPLC)	≤ 10.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.