Description

Idarubicinol is a significant metabolite and active form of the anthracycline antineoplastic agent idarubicin. This compound is critical for pharmaceutical research and development, particularly in the study of drug metabolism, efficacy, and pharmacokinetics. It is primarily utilized by research institutions, pharmaceutical manufacturers, and contract research organizations (CROs) engaged in oncology drug development and analytical method validation.

Application

• Pharmaceutical Reference Standard: Serves as a high-purity certified reference material (CRM) for quality control and analytical method development in drug manufacturing.
• Metabolite Research: Used in preclinical and clinical studies to understand the metabolic pathway, bioavailability, and activity profile of idarubicin.
• Bioanalytical Assay Development: Essential for developing and validating sensitive HPLC, LC-MS, or LC-MS/MS methods for quantifying idarubicin and its metabolites in biological matrices.
• Pharmacokinetic/Pharmacodynamic (PK/PD) Modeling: Provides key data points for modeling the concentration-effect relationship of anthracycline therapies.
• Impurity Profiling: Acts as a known impurity or degradation product standard to ensure the purity and stability of idarubicin active pharmaceutical ingredient (API) and finished dosage forms.
• Toxicology Studies: Employed in investigations to assess the comparative toxicity and side-effect profiles of idarubicin and its primary metabolites.

Basic Information

Product Name	Idarubicinol
CAS No.	86189-66-4
Molecular Formula	C26H27NO10
Molecular Weight	513.49 g/mol
Synonyms	13-Dihydroidarubicin; Idarubicinol Hydrochloride (salt form); 4-Demethoxydaunorubicinol; (7S,9S)-9-Acetyl-7-[(2R,4S,5S,6S)-4-amino-5-hydroxy-6-methyloxan-2-yl]oxy-6,9,11-trihydroxy-8,10-dihydro-7H-tetracene-5,12-dione; IDA-ol; Idarubicin Metabolite; Zavedos Metabolite
EINECS	Contact for details

Quality Control

Our Idarubicinol is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including identity confirmation by spectroscopic methods (IR, NMR), purity determination by HPLC, and control of specific impurities. A detailed Certificate of Analysis (COA) is provided with each shipment, ensuring traceability and compliance with research-grade standards.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and should be handled in a dry environment to prevent degradation.

Specification

Item	Specification
Appearance	Red to orange powder
Identification (IR)	Conforms to reference spectrum
Identification (HPLC)	Retention time corresponds to reference standard
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 2.0%
Residue on Ignition	≤ 0.5%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.