Description

Z-Ile-Nh2 is a protected amino acid derivative, specifically the benzyloxycarbonyl (Z or Cbz) protected form of L-isoleucine amide. This compound is a crucial chiral building block in the synthesis of complex peptides and peptidomimetics, offering excellent stereochemical control. It is primarily utilized by research institutions and pharmaceutical companies engaged in the development of novel therapeutic agents and bioactive compounds. Its high purity and defined structure make it indispensable for medicinal chemistry and advanced organic synthesis.

Application

• Solid-Phase Peptide Synthesis (SPPS): As a key intermediate for the controlled incorporation of isoleucine residues into peptide chains.
• Pharmaceutical Research: For the development and scale-up of peptide-based drug candidates, including hormone analogs and enzyme inhibitors.
• Combinatorial Chemistry: Used in libraries for high-throughput screening to discover new lead compounds with biological activity.
• Bioconjugation: Serves as a linker or spacer molecule in the creation of peptide-drug conjugates and other bioconjugates.
• Academic Research: A standard reagent in university and institutional labs for studying peptide structure-activity relationships (SAR).
• Process Chemistry: Employed in the pilot-scale and commercial manufacturing of approved peptide active pharmaceutical ingredients (APIs).

Basic Information

Product Name	Z-Ile-Nh2
CAS No.	86161-49-1
Molecular Formula	C14H20N2O3
Molecular Weight	264.32 g/mol
Synonyms	Nα-Cbz-L-isoleucinamide; Nα-Carbobenzoxy-L-isoleucinamide; Cbz-Ile-NH2; (2S,3S)-2-[[(Benzyloxy)carbonyl]amino]-3-methylpentanamide; Z-L-Isoleucinamide; Benzyl N-[(1S,2S)-1-(aminocarbonyl)-2-methylbutyl]carbamate; N-Carbobenzyloxy-L-isoleucine amide
EINECS	Contact for details

Quality Control

Our Z-Ile-Nh2 is manufactured under strict quality management systems to ensure batch-to-batch consistency and high purity, suitable for sensitive pharmaceutical applications. Each lot is accompanied by a comprehensive Certificate of Analysis (COA) detailing purity, chiral purity, and impurity profiles. We adhere to cGMP guidelines where applicable, and our quality protocols are designed to meet the stringent requirements of pharmaceutical research and development.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed in a dry environment to prevent degradation. For long-term storage, consider using a desiccant.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Assay (HPLC)	≥98.0%
Chiral Purity (HPLC)	≥99.0% ee
Loss on Drying	≤0.5%
Residue on Ignition	≤0.1%
Heavy Metals	≤10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.