Description

Fmoc-D-Phenylalanine CAS NO 86123-10-6 is a high-purity, enantiomerically pure amino acid derivative widely used as a critical building block in solid-phase peptide synthesis (SPPS). Its primary value lies in providing the D-isomer of phenylalanine with an Fmoc-protected α-amino group, enabling the controlled synthesis of complex peptides with specific chiral centers. This product is essential for researchers and manufacturers in the pharmaceutical, biotechnology, and life science sectors developing therapeutic peptides, diagnostic agents, and biochemical tools.

Application

• Solid-Phase Peptide Synthesis (SPPS): A fundamental building block for the automated, sequential assembly of custom peptides using Fmoc chemistry.
• Pharmaceutical Intermediates: Key raw material in the research and production of peptide-based active pharmaceutical ingredients (APIs) and drug candidates.
• Bioconjugation & Probe Development: Used to incorporate D-phenylalanine residues into fluorescent probes, affinity tags, and other bioconjugates for research.
• Enzyme Substrate & Inhibitor Design: Essential for creating chiral substrates and inhibitors to study enzyme specificity and function.
• Combinatorial Chemistry Libraries: A vital component in generating diverse libraries of peptide compounds for high-throughput screening in drug discovery.
• Academic & Industrial Research: Supports fundamental biochemical research, structural biology studies, and the development of novel biomaterials.

Basic Information

Product Name	Fmoc-D-Phenylalanine
CAS No.	86123-10-6
Molecular Formula	C24H21NO4
Molecular Weight	387.43 g/mol
Synonyms	N-[(9H-Fluoren-9-ylmethoxy)carbonyl]-D-phenylalanine; Fmoc-D-Phe-OH; (R)-2-((((9H-Fluoren-9-yl)methoxy)carbonyl)amino)-3-phenylpropanoic acid; N-Fmoc-D-phenylalanine; D-Fmoc-phenylalanine; Fmoc-D-2-amino-3-phenylpropionic acid; N-α-Fmoc-D-phenylalanine; Fmoc-D-Phenylalanin
EINECS	Contact for details

Quality Control

Our Fmoc-D-Phenylalanine is manufactured under strict quality management systems to ensure batch-to-batch consistency and high purity, suitable for demanding research and cGMP applications. Each lot undergoes comprehensive analytical testing, including HPLC for purity and chiral analysis to confirm enantiomeric excess. A detailed Certificate of Analysis (COA) is provided with every shipment, documenting specifications for identity, assay, and impurity profiles.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 15-25°C. This material is hygroscopic (moisture-sensitive); keep the original container tightly sealed in a desiccated environment to prevent degradation. For long-term storage, consider storing under an inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.5%
Chiral Purity (HPLC)	≥ 99.0% (D-isomer)
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.