Description

α-Difluoromethylputrescine is a specialized fluorinated derivative of the polyamine putrescine, designed as a potent and selective enzyme-activated irreversible inhibitor. This compound is of significant value in biochemical and pharmacological research, particularly for its role in studying polyamine metabolism and biosynthesis. It serves as a critical research tool for scientists and developers in the pharmaceutical, agrochemical, and life science industries who are investigating enzyme mechanisms and developing novel therapeutic agents.

Application

• Biochemical Research: As a mechanism-based inhibitor for the study of ornithine decarboxylase (ODC) and other polyamine biosynthetic enzymes.
• Pharmaceutical Development: A key intermediate or reference standard in the discovery of drugs targeting cancers, parasitic diseases, and conditions involving dysregulated cell growth.
• Agrochemical Research: Used in the development of novel plant growth regulators or herbicides that target polyamine pathways in plants.
• Enzyme Kinetics Studies: Employed to elucidate inhibition kinetics and the role of polyamines in cellular processes.
• Academic Research: A vital reagent for universities and research institutes conducting fundamental studies in biochemistry and molecular biology.
• Diagnostic Reagent Synthesis: Potential use as a building block for probes and assays used in diagnostic applications.

Basic Information

Product Name	α-Difluoromethylputrescine
CAS No.	86120-58-3
Molecular Formula	C5H12F2N2
Molecular Weight	138.16 g/mol
Synonyms	DFMP; α-Difluoromethylputrescine; 1,4-Diamino-2,2-difluorobutane; 2,2-Difluoroputrescine; (2,2-Difluoro-1,4-butanediamine); Eflornithine intermediate; Ornithine decarboxylase inhibitor; α-(Difluoromethyl)putrescine
EINECS	Contact for details

Quality Control

Our α-Difluoromethylputrescine is produced under a strict quality management system. Each batch undergoes rigorous analytical testing, including HPLC, NMR, and mass spectrometry, to ensure high purity and consistent performance. A comprehensive Certificate of Analysis (COA) detailing identity, purity, and impurity profiles is provided with every shipment to support your research and regulatory needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (typically 15-25°C). This compound is hygroscopic (moisture-sensitive) and should be handled under an inert atmosphere for long-term stability.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 95.0%
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.