Description

Angiostatin(R) Protein, Human is a recombinant protein fragment known for its potent anti-angiogenic properties, specifically inhibiting the formation of new blood vessels. This makes it a critical research tool and a molecule of significant interest in therapeutic development for conditions involving pathological angiogenesis. It is primarily utilized by biotechnology firms, academic research institutions, and pharmaceutical companies engaged in oncology, ophthalmology, and cardiovascular disease research. The product is supplied as a high-purity, lyophilized protein to ensure optimal stability and performance in demanding experimental and developmental workflows.

Application

• Biomedical Research: Fundamental studies on angiogenesis, endothelial cell biology, and tumor microenvironment dynamics.
• Drug Discovery & Preclinical Development: Used as a reference standard, positive control, or lead molecule in screening assays and efficacy models for anti-cancer and anti-angiogenic therapies.
• In Vitro Assay Development: Essential for establishing and validating cell-based and biochemical assays that measure angiogenesis inhibition.
• Mechanism of Action Studies: Investigating signaling pathways and molecular interactions involved in blood vessel growth regulation.
• Therapeutic Candidate Evaluation: Assessing the potency and specificity of novel anti-angiogenic compounds in comparative studies.

Basic Information

Product Name	Angiostatin(R) Protein, Human
CAS No.	86090-08-6
Molecular Formula	Contact for details
Molecular Weight	Contact for details
Synonyms	Angiostatin; Human Angiostatin; Plasminogen Kringle 1-3; K1-3; Angiostatin K1-3; Recombinant Human Angiostatin; Angiogenesis Inhibitor Protein
EINECS	Contact for details

Quality Control

Our Angiostatin(R) Protein, Human is produced and tested under stringent quality management systems. Each batch undergoes comprehensive analytical characterization, including purity assessment by SDS-PAGE and HPLC, identity confirmation, and biological activity testing to ensure consistent, reliable performance. A detailed Certificate of Analysis (COA) is provided with every shipment, documenting all critical quality attributes. We adhere to relevant guidelines for research-grade biologics to support your scientific and development needs.

Storage

Preserve in a tightly closed container, protected from light. For long-term storage, keep the lyophilized powder at -20°C or below. Upon reconstitution, aliquot and store at -80°C to avoid repeated freeze-thaw cycles. The product is hygroscopic (moisture-sensitive); ensure the vial is equilibrated to room temperature before opening to prevent condensation.

Specification

Item	Specification
Appearance	White or off-white lyophilized powder
Purity (SDS-PAGE)	> 95%
Purity (HPLC)	> 98%
Identification (Mass Spec)	Consistent with theoretical molecular weight
Endotoxin Level	< 1.0 EU/µg
Biological Activity	Inhibits endothelial cell proliferation in a dose-dependent manner
Solubility	Soluble in aqueous buffers

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.