Description

L-Threonine Benzyl Ester Hemioxalate is a protected amino acid derivative primarily used as a key chiral building block in organic synthesis. This compound is critical for researchers and manufacturers requiring high-purity intermediates for the development of complex molecules. It is particularly valuable in the pharmaceutical industry for the synthesis of peptides, peptidomimetics, and other bioactive compounds where the threonine side chain functionality must be selectively introduced.

Application

• Pharmaceutical Intermediate: A crucial chiral synthon for the synthesis of active pharmaceutical ingredients (APIs), especially in peptide-based drug discovery and development.
• Peptide Synthesis: Used in solid-phase and solution-phase peptide synthesis (SPPS) to incorporate L-threonine residues with the carboxylic acid group protected as a benzyl ester.
• Biochemical Research: Serves as a standard or reagent in proteomics and enzymology studies investigating amino acid metabolism and protein structure-function relationships.
• Asymmetric Synthesis: Employed as a starting material or auxiliary in the preparation of non-proteinogenic amino acids and other enantiomerically pure compounds.
• Fine Chemical Production: Acts as a building block for the manufacture of specialty chemicals, including flavors, fragrances, and advanced materials.

Basic Information

Product Name	L-Threonine Benzyl Ester Hemioxalate
CAS No.	86088-59-7
Molecular Formula	C14H19NO6 • 0.5(C2H2O4)
Molecular Weight	328.30 g/mol (for the hemioxalate salt form)
Synonyms	L-Threonine, benzyl ester, hemioxalate; (2S,3R)-2-Amino-3-hydroxybutanoic acid benzyl ester hemioxalate; Benzyl L-threoninate hemioxalate; H-Thr-OBzl • 0.5(Oxalic Acid); Threonine benzyl ester oxalate (1:0.5); L-Threonine O-benzyl ester hemioxalate; Fmoc-Thr(Bzl)-OH precursor
EINECS	Contact for details

Quality Control

Our L-Threonine Benzyl Ester Hemioxalate is produced under strict quality management systems. Each batch undergoes comprehensive analytical testing to ensure identity, purity, and consistency. We provide Certificates of Analysis (COA) detailing key parameters such as assay, enantiomeric purity, and impurity profiles. While not typically compendial, our quality standards align with the principles of cGMP for pharmaceutical intermediates, ensuring reliability for critical research and production applications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and should be handled in a dry environment to prevent degradation. Keep away from incompatible materials.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 98.0%
Optical Rotation [α]D20	Contact for details
Water Content (KF)	≤ 1.0%
Heavy Metals	≤ 20 ppm
Residue on Ignition	≤ 0.2%
Single Impurity (HPLC)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.