Description

H-D-Thr(Bzl)-Oh is a protected derivative of the non-natural amino acid D-threonine, where the hydroxyl group is protected by a benzyl (Bzl) ether. This compound is a critical chiral building block in the synthesis of complex peptides and peptidomimetics, enabling precise control over stereochemistry and side-chain functionality. It is primarily utilized by pharmaceutical R&D teams and fine chemical manufacturers engaged in the development of therapeutic peptides, protease inhibitors, and other bioactive molecules.

Application

• Solid-Phase Peptide Synthesis (SPPS): A key chiral intermediate for the controlled incorporation of D-threonine residues into peptide chains.
• Pharmaceutical Intermediates: Serves as a building block for the research and production of novel peptide-based drugs and active pharmaceutical ingredients (APIs).
• Protease Inhibitor Development: Used in the design and synthesis of inhibitors targeting specific enzymes, such as HIV protease.
• Biochemical Research: Employed in studies exploring protein structure-function relationships, enzyme specificity, and chiral recognition.
• Combinatorial Chemistry Libraries: A valuable component for generating diverse libraries of chiral compounds for high-throughput screening.
• Glycopeptide Synthesis: Acts as a precursor or intermediate in the synthesis of complex glycopeptides where the threonine side chain is a glycosylation site.

Basic Information

Product Name	H-D-Thr(Bzl)-Oh
CAS No.	86062-17-1
Molecular Formula	C11H15NO3
Molecular Weight	209.24 g/mol
Synonyms	D-Threonine, O-benzyl-; (2R,3S)-2-Amino-3-(benzyloxy)butanoic acid; H-D-Thr(Bzl)-OH; D-O-Benzylthreonine; (R,S)-2-Amino-3-(benzyloxy)butyric acid (D-form); Boc-D-Thr(Bzl)-OH precursor; Fmoc-D-Thr(Bzl)-OH precursor; D-3-(Benzyloxy)threonine
EINECS	Contact for details

Quality Control

Our H-D-Thr(Bzl)-Oh is manufactured under strict quality management systems to ensure high purity and batch-to-batch consistency, suitable for demanding research and cGMP applications. Each lot is accompanied by a comprehensive Certificate of Analysis (COA) detailing purity, chiral purity, and impurity profiles. We adhere to relevant ICH guidelines and can support customer audits and regulatory filings.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 15-25°C. This material is hygroscopic (moisture-sensitive) and should be handled in a dry environment to prevent degradation. For long-term storage, consider desiccants or inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Assay (HPLC)	≥98.0%
Chiral Purity (HPLC)	≥99.0% de (D-isomer)
Loss on Drying	≤1.0%
Residue on Ignition	≤0.1%
Heavy Metals	≤10 ppm
Single Impurity (HPLC)	≤0.5%
Total Impurities (HPLC)	≤2.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.