Description

Fmoc-L-Aspartic Acid 4-Benzyl Ester is a protected derivative of the amino acid L-aspartic acid, specifically engineered for solid-phase peptide synthesis (SPPS). This compound is a critical building block for the controlled introduction of aspartic acid into peptide chains, where the Fmoc group provides orthogonal protection and the benzyl ester safeguards the side-chain carboxyl function. It is an essential reagent for researchers and manufacturers in pharmaceutical development, biotechnology, and advanced materials science who require high-purity, reliable intermediates for complex peptide assembly.

Application

• Solid-Phase Peptide Synthesis (SPPS): A fundamental Fmoc-protected amino acid for the sequential construction of peptides on resin supports.
• Pharmaceutical Intermediates: Used in the research and production of therapeutic peptides, including hormone analogs and enzyme inhibitors.
• Bioconjugation: Serves as a key component for creating peptide-protein or peptide-small molecule conjugates for drug delivery and diagnostics.
• Combinatorial Chemistry: Employed in libraries for high-throughput screening to discover new bioactive peptide leads.
• Academic & Industrial Research: Essential for biochemical studies involving protein structure, function, and protein-protein interactions.
• Material Science: Used in the synthesis of peptide-based polymers and biomaterials with specific functional properties.

Basic Information

Product Name	Fmoc-L-Aspartic Acid 4-Benzyl Ester
CAS No.	86060-84-6
Molecular Formula	C26H23NO6
Molecular Weight	445.46 g/mol
Synonyms	Fmoc-Asp(OBzl)-OH; N-(9-Fluorenylmethoxycarbonyl)-L-aspartic acid 4-benzyl ester; Fmoc-L-Asp(OBzl)-OH; (2S)-2-[(9H-Fluoren-9-ylmethoxy)carbonylamino]butanedioic acid 4-benzyl ester; Fmoc-Asp-OBzl; N-α-Fmoc-L-aspartic acid β-benzyl ester; Fmoc-Aspartic acid benzyl ester; L-Aspartic acid, N-[(9H-fluoren-9-ylmethoxy)carbonyl]-, 4-benzyl ester
EINECS	Contact for details

Quality Control

Our Fmoc-L-Aspartic Acid 4-Benzyl Ester is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity, chiral analysis to confirm enantiomeric purity, and NMR for structural confirmation. We provide full traceability and Certificates of Analysis (COA) with every shipment to ensure compliance with your research and cGMP-grade production requirements.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 2-8°C. This product is hygroscopic (moisture-sensitive) and should be handled under anhydrous conditions to maintain stability and purity. Allow the container to reach room temperature before opening to prevent condensation.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥98.5%
Specific Rotation	[α]20/D: Contact for details
Water Content (KF)	≤0.5%
Heavy Metals	≤10 ppm
Residual Solvents (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.