Description

Cefixime O,O''-Diphenylmethane CAS NO 86027-28-3 is a key pharmaceutical intermediate, specifically a diphenylmethyl-protected derivative of the third-generation cephalosporin antibiotic, Cefixime. This compound is of critical importance for ensuring high-purity synthesis and optimal yield in the final active pharmaceutical ingredient (API) manufacturing process. It is primarily required by manufacturers in the pharmaceutical and fine chemical sectors engaged in the production of advanced antibiotic formulations.

Application

• Pharmaceutical Intermediate: Serves as a crucial protected intermediate in the multi-step synthesis of the antibiotic Cefixime.
• API (Active Pharmaceutical Ingredient) Manufacturing: Used in controlled synthesis processes to produce high-purity Cefixime for final dosage forms.
• Research & Development: Employed in pharmaceutical R&D for developing new synthetic routes, process optimization, and impurity profiling studies.
• Fine Chemical Synthesis: Acts as a specialized building block for synthesizing novel cephalosporin analogs and derivatives in advanced organic chemistry.
• Contract Manufacturing: Supplied to CDMOs (Contract Development and Manufacturing Organizations) for cGMP-compliant production of antibiotic drugs.
• Reference Standard: Can be utilized as a process impurity reference standard in quality control laboratories for HPLC analysis.

Basic Information

Product Name	Cefixime O,O''-Diphenylmethane
CAS No.	86027-28-3
Molecular Formula	C27H25N5O7S2
Molecular Weight	595.65 g/mol
Synonyms	Cefixime Diphenylmethyl Ester; Cefixime DPM Ester; (6R,7R)-7-[(Z)-2-(2-Aminothiazol-4-yl)-2-(carboxymethoxyimino)acetamido]-3-ethenyl-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic Acid O,O''-Diphenylmethane Derivative; Cefixime O,O-Bis(phenylmethyl) Ester; Cefixime Dibenzyl Ester (common misnomer); Cefixime Protective Intermediate; 86027-28-3
EINECS	Contact for details

Quality Control

Our Cefixime O,O''-Diphenylmethane is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC for purity and identity confirmation (IR, NMR), to ensure it meets exacting standards suitable for pharmaceutical intermediate use. Certificates of Analysis (COA) detailing all specifications and test results are available upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at controlled room temperature (15-25°C). Due to its hygroscopic nature, the container must be kept tightly sealed in a dry environment to prevent moisture absorption. Keep away from incompatible materials.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Conforms to reference
Assay (HPLC)	≥ 98.0%
Related Substances (HPLC)	Total impurities ≤ 2.0%
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.2%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.