Description

2-Benzyloxycarbonylamino-3-Hydroxy-Butyric Acid is a protected amino acid derivative, specifically a Cbz-protected threonine analog, serving as a crucial chiral building block in organic synthesis. This compound matters for its role in facilitating the controlled synthesis of complex peptides and pharmaceutical intermediates, where protecting group chemistry is essential. It is primarily needed by research institutions and manufacturers in the pharmaceutical, biotechnology, and fine chemical sectors for developing new therapeutic agents and advanced materials.

Application

• Pharmaceutical Intermediate: A key chiral synthon in the research and production of peptide-based drugs and active pharmaceutical ingredients (APIs).
• Peptide Synthesis: Used in solid-phase and solution-phase peptide synthesis as a protected form of a modified threonine residue.
• Bioconjugation: Serves as a linker or spacer molecule in the development of antibody-drug conjugates (ADCs) and other bioconjugates.
• Chemical Biology Research: Employed in the study of enzyme mechanisms and protein-protein interactions where specific amino acid analogs are required.
• Fine Chemical Synthesis: Utilized as a building block for the preparation of complex natural products, macrocycles, and other specialty organic molecules.
• Protecting Group Chemistry: Demonstrates the application of the benzyloxycarbonyl (Cbz) protecting group, which is cleavable under mild hydrogenolytic conditions.

Basic Information

Product Name	2-Benzyloxycarbonylamino-3-Hydroxy-Butyric Acid
CAS No.	85995-53-5
Molecular Formula	C12H15NO5
Molecular Weight	253.25 g/mol
Synonyms	N-Carbobenzyloxy-L-threonine; N-Cbz-L-threonine; N-[(Benzyloxy)carbonyl]-L-threonine; (2S,3R)-2-[[(Benzyloxy)carbonyl]amino]-3-hydroxybutanoic acid; Z-Thr-OH; Cbz-Thr-OH; N-Cbz-threonine; L-Threonine, N-[(phenylmethoxy)carbonyl]-
EINECS	Contact for details

Quality Control

Our 2-Benzyloxycarbonylamino-3-Hydroxy-Butyric Acid is produced under a strict quality management system. Each batch undergoes rigorous analytical testing, including chiral purity verification, to ensure it meets the high standards required for research and pharmaceutical applications. A comprehensive Certificate of Analysis (COA) detailing purity, identity, and impurity profiles is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and must be kept under dry, inert conditions to prevent degradation. Keep away from incompatible materials.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Assay (HPLC)	≥98.0%
Chiral Purity (HPLC)	≥99.0% ee
Loss on Drying	≤0.5%
Residue on Ignition	≤0.1%
Heavy Metals	≤10 ppm
Single Impurity (HPLC)	≤0.5%
Total Impurities (HPLC)	≤2.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.