Description

2-Trifluoromethylbenzylsulfonyl Chloride is a high-purity, reactive organosulfur intermediate essential for advanced chemical synthesis. Its core value lies in its trifluoromethyl and sulfonyl chloride functional groups, which enable the precise introduction of fluorinated sulfonamide motifs into target molecules. This compound is critically needed by research chemists and process development scientists in the pharmaceutical and agrochemical industries for the development of novel active ingredients.

Application

• Pharmaceutical Intermediate: A key building block for synthesizing sulfonamide-based drug candidates, particularly in areas like enzyme inhibitors and receptor antagonists.
• Agrochemical Synthesis: Used in the research and production of advanced herbicides, fungicides, and pesticides, where the trifluoromethyl group enhances biological activity and metabolic stability.
• Material Science Research: Serves as a precursor for creating specialized polymers and functional materials with unique surface properties.
• Chemical Biology Probes: Employed in the development of activity-based probes and covalent inhibitors for target identification and validation studies.
• Custom Synthesis & Contract Manufacturing: A vital reagent for fine chemical and CDMO companies offering bespoke synthesis services for complex molecules.

Basic Information

Product Name	2-Trifluoromethylbenzylsulfonyl Chloride
CAS No.	85952-32-5
Molecular Formula	C8H6ClF3O2S
Molecular Weight	258.64 g/mol
Synonyms	α,α,α-Trifluoro-o-toluenesulfonyl Chloride; 2-(Trifluoromethyl)benzenemethanesulfonyl Chloride; 1-(Chlorosulfonyl)methyl-2-(trifluoromethyl)benzene; 2-(Trifluoromethyl)benzylsulfonyl Chloride; o-Trifluoromethylbenzylsulfonyl Chloride; 2-(Trifluoromethyl)phenylmethanesulfonyl Chloride; (2-Trifluoromethylphenyl)methanesulfonyl Chloride
EINECS	Contact for details

Quality Control

Our 2-Trifluoromethylbenzylsulfonyl Chloride is manufactured under strict quality management systems. Every batch undergoes rigorous analytical testing, including HPLC, NMR, and IR spectroscopy, to ensure identity, purity, and consistency. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing all specifications and test results. Our commitment to quality assurance supports your R&D and scale-up processes with reliable, high-grade material.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed under an inert atmosphere (e.g., nitrogen or argon) after opening to prevent decomposition. Keep away from strong bases, oxidizers, and moisture.

Specification

Item	Specification
Appearance	White to off-white crystalline powder or solid
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.