Description

19-Nor-10-Keto-25-Hydroxyvitamin D3 is a high-purity, synthetic vitamin D analog with significant research and pharmaceutical development potential. This compound is valued for its role as a key intermediate in the synthesis of advanced vitamin D receptor modulators and active metabolites. It is primarily sought by research institutions and pharmaceutical companies engaged in metabolic bone disease research, oncology studies, and the development of novel therapeutics.

Application

• Pharmaceutical Intermediate: Critical starting material or intermediate in the synthesis of advanced vitamin D analogs and active pharmaceutical ingredients (APIs).
• Biochemical Research: Used as a reference standard and probe in studies investigating vitamin D metabolism, receptor binding, and signaling pathways.
• Drug Discovery: Serves as a core scaffold for developing new therapeutic agents targeting conditions like osteoporosis, psoriasis, and certain cancers.
• Analytical Standard: Employed in analytical laboratories for method development, calibration, and quality control of related vitamin D compounds.
• Metabolic Studies: Utilized in research to understand the enzymatic conversion and biological activity of modified vitamin D metabolites.

Basic Information

Product Name	19-Nor-10-Keto-25-Hydroxyvitamin D3
CAS No.	85925-90-2
Molecular Formula	C₂₆H₄₀O₃
Molecular Weight	400.60 g/mol
Synonyms	19-Nor-10-Oxo-25-Hydroxyvitamin D3; 10-Keto-19-Nor-25-Hydroxycholecalciferol; (5Z,7E)-9,10-Secocholesta-5,7,10(19)-triene-1,3,25-triol, 19-nor-10-oxo-; 25-Hydroxy-19-nor-10-oxovitamin D3; 19-Nor-10-Oxo-25-OH-D3
EINECS	Contact for details

Quality Control

Our 19-Nor-10-Keto-25-Hydroxyvitamin D3 is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity and identity confirmation by spectroscopic methods (NMR, IR, MS). We provide Certificates of Analysis (COA) with each shipment, detailing batch-specific results. Production can be aligned with cGMP guidelines for advanced pharmaceutical applications upon request.

Storage

Preserve in a tightly closed container, protected from light. Store under an inert atmosphere (e.g., nitrogen or argon) at controlled room temperature (15-25°C) or as specified on the label or COA. This product is light-sensitive and easily oxidized; prolonged exposure to air, light, or elevated temperatures should be avoided to maintain stability and potency.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (HPLC)	Conforms to reference standard
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Related Substances (HPLC)	Total impurities ≤ 2.0%
Solvent Residue (GC)	Meets ICH guidelines
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.