Description

5,10-Methylenetetrahydrofolate Polyglutamate is a biologically active, polyglutamylated form of folate, a critical coenzyme in one-carbon metabolism. This compound is essential for the synthesis of nucleotides and amino acids, making it a vital component in advanced biochemical research and high-purity pharmaceutical development. It is primarily utilized by research institutions, diagnostic manufacturers, and pharmaceutical companies developing targeted therapies and nutritional supplements.

Application

• Biochemical Research: Used as a key substrate and cofactor in enzymatic studies of folate-dependent pathways, including thymidylate and purine synthesis.
• Pharmaceutical Intermediates: Serves as a high-purity active pharmaceutical ingredient (API) or critical intermediate in the synthesis of advanced therapeutic agents targeting metabolic disorders.
• Diagnostic Reagents: Employed in the formulation of clinical diagnostic kits and assays for measuring folate status and related enzymatic activities.
• Cell Culture & Microbiology: Acts as a specialized growth factor in defined cell culture media for cultivating fastidious microorganisms and mammalian cell lines.
• Nutritional Science: Investigated for use in advanced nutraceutical formulations designed for enhanced bioavailability and targeted metabolic support.

Basic Information

Product Name	5,10-Methylenetetrahydrofolate Polyglutamate
CAS No.	85917-14-2
Molecular Formula	Contact for details
Molecular Weight	Contact for details
Synonyms	5,10-CH2-THF Polyglutamate; 5,10-Methylene-THF Poly-γ-glutamate; 5,10-Methylenetetrahydropteroylpolyglutamate; NSC 139490; (6S)-5,10-Methylenetetrahydrofolate Polyglutamate; 5,10-Methylene-5,6,7,8-tetrahydrofolate Polyglutamate; 5,10-Methylene-THFA Polyglutamate
EINECS	Contact for details

Quality Control

Our 5,10-Methylenetetrahydrofolate Polyglutamate is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC for purity and identity confirmation, to ensure it meets exacting standards for research and development. Certificates of Analysis (COA) with detailed chromatographic data are provided to guarantee traceability and batch-to-batch consistency.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below under an inert atmosphere (e.g., argon or nitrogen) to prevent oxidation and hydrolysis. The container must be kept in a dry environment to minimize exposure to moisture. Allow the sealed container to equilibrate to room temperature before opening to prevent condensation.

Specification

Item	Specification
Appearance	Yellow to orange powder or solid
Identification (HPLC/UV)	Conforms to reference standard
Assay (HPLC)	≥ 95.0%
Related Substances (HPLC)	Total impurities ≤ 5.0%
Solubility	Soluble in basic aqueous solutions
Water Content (KF)	≤ 3.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.