Description

(+)-o-Isopropylidene-2,3-Dihydroxy-1,4-Bis[Bis(2-Methylphenyl)Phosphino]Butane CAS NO 85849-33-8 is a high-value, chiral diphosphine ligand essential for asymmetric catalysis. Its primary value lies in enabling highly enantioselective transformations, which are critical for producing single-isomer pharmaceutical intermediates and fine chemicals. This product is specifically needed by R&D chemists and process engineers in the pharmaceutical, agrochemical, and specialty chemical industries for developing efficient and selective synthetic routes.

Application

• Asymmetric Hydrogenation Catalysis: A key ligand for the enantioselective reduction of prochiral olefins, ketones, and imines in API synthesis.
• Pharmaceutical Intermediate Manufacturing: Used in the production of chiral active pharmaceutical ingredients (APIs) requiring high optical purity.
• Agrochemical Synthesis: Employed in the creation of enantiomerically pure herbicides, fungicides, and plant growth regulators.
• Fine Chemical Production: Facilitates asymmetric C-C and C-X bond-forming reactions for high-value fragrance and flavor compounds.
• Academic & Industrial R&D: A vital tool for methodology development in organic synthesis and catalysis research.
• Catalyst Precursor Preparation: Serves as a sophisticated ligand for transition metal complexes (e.g., Rh, Ru, Ir) used in homogeneous catalysis.

Basic Information

Item	Details
Product Name	(+)-o-Isopropylidene-2,3-Dihydroxy-1,4-Bis[Bis(2-Methylphenyl)Phosphino]Butane
CAS No.	85849-33-8
Molecular Formula	C38H44O2P2
Molecular Weight	594.70 g/mol
Synonyms	(+)-DIOP; (2R,3R)-(-)-2,3-O-Isopropylidene-2,3-dihydroxy-1,4-bis(diphenylphosphino)butane; (R,R)-DIOP; (-)-DIOP; (2R,3R)-1,4-Bis(diphenylphosphino)-2,3-O-isopropylidene-2,3-butanediol; 1,4-Bis(diphenylphosphino)-2,3-O-isopropylidene-2,3-butanediol; DIOP ligand; 85849-33-8
EINECS	Contact for details

Quality Control

Our (+)-o-Isopropylidene-2,3-Dihydroxy-1,4-Bis[Bis(2-Methylphenyl)Phosphino]Butane is produced and handled under strict quality management protocols to ensure batch-to-batch consistency and high chiral purity. Each lot undergoes comprehensive analytical testing, including HPLC for enantiomeric excess (ee) and chemical purity, NMR for structural confirmation, and specific rotation measurement. A detailed Certificate of Analysis (COA) documenting all specifications is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Due to its sensitivity to oxidation, this material should be stored under an inert atmosphere (argon or nitrogen) in a cool, dry place. Recommended long-term storage temperature is 2-8°C. Allow the sealed container to reach room temperature before opening to prevent moisture condensation.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Enantiomeric Excess (ee)	≥ 99.0%
Specific Rotation [α]	-20.0° to -24.0° (c=1 in benzene)
Melting Point	89 - 93 °C
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.