Description

Cephradine L-Arginine CAS NO 85760-50-5 is a pharmaceutical-grade salt complex formed between the first-generation cephalosporin antibiotic, Cephradine, and the amino acid L-Arginine. This combination enhances the stability and solubility profile of the active pharmaceutical ingredient, making it a critical intermediate for the formulation of injectable and oral antibiotic preparations. It is primarily required by pharmaceutical manufacturers and research institutions engaged in the development and production of broad-spectrum antibacterial drugs.

Application

• Pharmaceutical API Intermediate: Primary use as a key starting material or intermediate in the synthesis of finished dosage forms of Cephradine.
• Injectable Formulations: Utilized in the production of sterile injectable solutions where enhanced solubility and stability are paramount.
• Oral Solid Dosages: Serves as an active ingredient in the manufacture of capsules and tablets for oral antibiotic therapy.
• Veterinary Pharmaceuticals: Applied in the development of antibacterial treatments for veterinary use.
• Clinical Research: Used as a reference standard or raw material in pharmacological and microbiological research studies.
• Generic Drug Manufacturing: Essential for companies producing generic versions of cephalosporin-based antibiotics.

Basic Information

Product Name	Cephradine L-Arginine
CAS No.	85760-50-5
Molecular Formula	C20H34N8O8S
Molecular Weight	546.60 g/mol
Synonyms	Cephradine Arginine; Cephradine L-Arginine Salt; Cephradine Argininate; (6R,7R)-7-[(R)-2-Amino-2-(1,4-cyclohexadien-1-yl)acetamido]-3-methyl-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic acid compound with L-arginine; Velosef Arginine; Sefril with Arginine
EINECS	Contact for details

Quality Control

Our Cephradine L-Arginine is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing to ensure it meets high-purity standards suitable for pharmaceutical applications. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing parameters such as assay, related substances, and residual solvents. Our quality commitment aligns with cGMP principles, and we can support documentation for regulatory submissions.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This material is hygroscopic (moisture-sensitive) and must be kept in a dry environment to prevent degradation. The container should be kept tightly sealed when not in use.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to reference spectrum
Identification (HPLC)	Retention time corresponds to reference standard
Assay (HPLC)	98.0% - 102.0% (on anhydrous basis)
Water Content (KF)	≤ 5.0%
Related Substances (HPLC)	Total impurities ≤ 2.0% Any single impurity ≤ 1.0%
Residual Solvents (GC)	Complies with ICH Q3C guidelines
Specific Rotation	+80° to +90° (c=1 in water)
pH (1% solution)	5.0 - 7.0

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.