Description

Mono-Iodo Amiodarone CAS NO 85642-08-6 is a key iodinated derivative of the potent antiarrhythmic agent amiodarone. This compound is of significant value as a crucial intermediate or reference standard in pharmaceutical research and development, particularly for studying drug metabolism, pharmacokinetics, and for the synthesis of novel therapeutic agents. It is primarily required by pharmaceutical manufacturers, contract research organizations (CROs), and academic institutions engaged in advanced cardiovascular drug discovery and analytical method development.

Application

• Pharmaceutical Intermediate: Serves as a critical building block in the synthesis of novel amiodarone analogs and related antiarrhythmic compounds.
• Metabolite Reference Standard: Used as an analytical standard in HPLC, LC-MS, and other chromatographic methods to identify and quantify amiodarone metabolites in biological matrices for pharmacokinetic studies.
• Research Chemical: Employed in biochemical and pharmacological research to investigate the structure-activity relationships (SAR) of iodinated benzofuran derivatives.
• Impurity Standard: Essential for quality control laboratories to monitor and control process-related impurities in amiodarone hydrochloride active pharmaceutical ingredient (API) manufacturing.
• Labeled Compound Synthesis: Acts as a precursor for the development of radiolabeled (e.g., with I-125) tracers for imaging and biodistribution studies.

Basic Information

Product Name	Mono-Iodo Amiodarone
CAS No.	85642-08-6
Molecular Formula	C25H28I2NO3
Molecular Weight	660.21 g/mol
Synonyms	2-Butyl-3-benzofuranyl 4-[2-(diethylamino)ethoxy]-3,5-diiodophenyl ketone; 4-[2-(Diethylamino)ethoxy]-3,5-diiodobenzoyl-2-butylbenzofuran; Amiodarone Iodinated Derivative; 3,5-Diiodo-4-[2-(diethylamino)ethoxy]benzoyl-2-butylbenzofuran; DEA-Iodo Amiodarone; Benzofuran-2-yl(4-(2-(diethylamino)ethoxy)-3,5-diiodophenyl)methanone
EINECS	Contact for details

Quality Control

Our Mono-Iodo Amiodarone is produced and tested under a strict quality management system. Each batch undergoes comprehensive analytical testing, including identification by spectroscopic methods (IR, NMR), purity assay by HPLC, and control of related substances and residual solvents, to ensure it meets high-purity standards suitable for research and development. A detailed Certificate of Analysis (COA) is provided with each shipment, documenting all test results against predefined specifications.

Storage

Preserve in a tightly closed container, protected from light. Store at controlled room temperature (15-25°C) in a dry, well-ventilated area. Keep the container sealed to protect the contents from moisture.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Purity (HPLC)	≥ 98.0%
Related Substances (HPLC)	Total impurities ≤ 2.0% Any single impurity ≤ 1.0%
Residual Solvents (GC)	Complies with ICH Q3C guidelines
Loss on Drying	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.