Description

N2-[(1,1-Dimethylethoxy)Carbonyl]-Dl-Glutamine is a protected derivative of the amino acid glutamine, where the amine group is shielded by a tert-butoxycarbonyl (Boc) protecting group. This modification is critical for enabling selective chemical reactions in complex multi-step syntheses, particularly in peptide and pharmaceutical manufacturing. It is an essential building block for researchers and manufacturers in the life sciences sector who require high-purity intermediates for the development of novel therapeutic compounds and biochemical tools.

Application

• Peptide Synthesis: A key protected intermediate in solid-phase and solution-phase peptide synthesis (SPPS) for the controlled incorporation of glutamine residues.
• Pharmaceutical Intermediates: Serves as a crucial building block in the research and production of active pharmaceutical ingredients (APIs) and prodrugs.
• Biochemical Research: Used in the study of enzyme substrates, metabolic pathways, and the synthesis of labeled compounds for tracer studies.
• Protecting Group Chemistry: Employed in organic synthesis where selective protection and deprotection of amino acid functional groups are required.
• Combinatorial Chemistry: Utilized in the generation of diverse chemical libraries for drug discovery and screening applications.

Basic Information

Product Name	N2-[(1,1-Dimethylethoxy)Carbonyl]-Dl-Glutamine
CAS No.	85535-45-1
Molecular Formula	C₁₀H₁₈N₂O₅
Molecular Weight	246.26 g/mol
Synonyms	Boc-DL-Glutamine; N-Boc-DL-Glutamine; N-(tert-Butoxycarbonyl)-DL-glutamine; DL-Glutamine, N-[(1,1-dimethylethoxy)carbonyl]-; (RS)-2-[(tert-Butoxycarbonyl)amino]-4-carbamoylbutanoic acid; Boc-Gln-OH (racemic); N-α-Boc-DL-glutamine; N-tert-Butoxycarbonyl-DL-glutamine
EINECS	Contact for details

Quality Control

Our N2-[(1,1-Dimethylethoxy)Carbonyl]-Dl-Glutamine is manufactured under strict quality management systems. Each batch is subjected to comprehensive analytical testing, including HPLC for purity, chiral analysis, and identity confirmation by spectroscopic methods, to ensure it meets the stringent requirements for research and pharmaceutical-grade intermediates. A Certificate of Analysis (COA) detailing all specifications is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 15-25°C. This compound is hygroscopic (moisture-sensitive); ensure the container is sealed tightly after each use to prevent degradation from atmospheric moisture.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Optical Rotation	Specific rotation provided on COA
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.