Description

4-Chloro-2-(Trifluoromethyl)Phenylacetonitrile is a versatile and high-value fluorinated aromatic nitrile building block. This compound is critical for the synthesis of advanced pharmaceutical intermediates and agrochemicals, where its unique trifluoromethyl and chloro substituents impart desirable biological activity and metabolic stability. It is primarily sought by R&D chemists and process development scientists in the pharmaceutical, agrochemical, and specialty chemical industries for constructing complex molecular architectures.

Application

• Pharmaceutical Intermediate: A key synthon for the development of active pharmaceutical ingredients (APIs), particularly in CNS and anti-inflammatory drug candidates.
• Agrochemical Synthesis: Used in the manufacture of advanced herbicides and fungicides, leveraging the trifluoromethyl group for enhanced efficacy and environmental profile.
• Ligand and Catalyst Development: Serves as a precursor for specialized ligands in asymmetric catalysis and metal-organic frameworks (MOFs).
• Material Science Research: Employed in the synthesis of fluorinated polymers and liquid crystals for electronic and optical applications.
• Custom Synthesis & Contract Manufacturing: A fundamental building block for custom chemical synthesis services targeting novel chemical entities.

Basic Information

Product Name	4-Chloro-2-(Trifluoromethyl)Phenylacetonitrile
CAS No.	85386-80-7
Molecular Formula	C9H5ClF3N
Molecular Weight	219.59 g/mol
Synonyms	2-(4-Chloro-2-(trifluoromethyl)phenyl)acetonitrile; (4-Chloro-2-(trifluoromethyl)phenyl)acetonitrile; α-(4-Chloro-α,α,α-trifluoro-o-tolyl)acetonitrile; 4-Chloro-α,α,α-trifluoro-o-toluonitrile; 85386-80-7; 4-Chloro-2-trifluoromethylphenylacetonitrile
EINECS	Contact for details

Quality Control

Our 4-Chloro-2-(Trifluoromethyl)Phenylacetonitrile is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, GC, NMR, and IR spectroscopy, to ensure identity, purity, and consistency. Certificates of Analysis (COA) with detailed specifications are provided for every shipment, supporting your quality assurance and regulatory compliance needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at room temperature (15-25°C). Keep away from strong bases, strong oxidizing agents, and sources of ignition. For long-term storage, consider under an inert atmosphere to maintain optimal purity.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Melting Point	Contact for details
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.