Description

Lhrh, Pglu(1)-Phe(2)-Trp(3)-Ser(4)-n-ε-Azidobenzoyl-Lys(6)- CAS NO 85371-77-3 is a synthetic, azide-functionalized analog of the Luteinizing Hormone-Releasing Hormone (LHRH) peptide. This modified peptide is a critical research tool, offering a unique chemical handle for site-specific conjugation via click chemistry, enabling the study of hormone-receptor interactions and targeted drug delivery systems. It is primarily utilized by pharmaceutical R&D teams, academic researchers in endocrinology, and bioconjugation specialists developing next-generation peptide therapeutics and diagnostic probes.

Application

• Bioconjugation & Probe Development: The azido group enables efficient, site-specific labeling with alkyne-bearing fluorophores, affinity tags, or drug payloads via copper-catalyzed azide-alkyne cycloaddition (CuAAC).
• Receptor Binding & Mechanism Studies: Used to investigate the binding affinity and internalization pathways of LHRH receptors (LHRH-R) overexpressed in certain cancers.
• Targeted Drug Delivery Research: Serves as a targeting ligand in the design of peptide-drug conjugates (PDCs) aimed at cancers of the reproductive system.
• Structural-Activity Relationship (SAR) Analysis: A key intermediate for studying the impact of specific lysine modifications on the potency and stability of LHRH analogs.
• Diagnostic Imaging Agent Precursor: Acts as a precursor for radiolabeled (e.g., with 18F, 64Cu, 68Ga) compounds for PET imaging research.
• Affinity Chromatography Ligand: Can be immobilized on solid supports to create resins for the purification of LHRH receptor proteins or antibodies.

Basic Information

Product Name	Lhrh, Pglu(1)-Phe(2)-Trp(3)-Ser(4)-n-ε-Azidobenzoyl-Lys(6)- CAS NO 85371-77-3
CAS No.	85371-77-3
Molecular Formula	C64H83N17O13
Molecular Weight	1274.5 g/mol
Synonyms	Azido-LHRH; LHRH Azide; pGlu-His-Trp-Ser-Tyr-AzBz-Lys-Leu-Arg-Pro-Gly-NH2; Luteinizing Hormone-Releasing Hormone Azide Analog; Gonadorelin Azide Derivative; [AzBz-Lys6]-LHRH; 85371-77-3; LHRH Peptide Azide
EINECS	Contact for details

Quality Control

This high-purity peptide is manufactured under GMP-like conditions for research use. Every batch undergoes comprehensive analytical characterization to ensure identity, purity, and consistency. Certificates of Analysis (COA) are provided, detailing results from HPLC, MS, and amino acid analysis. Our quality system is designed to support regulatory filings for preclinical research.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below in a dedicated freezer. This product is hygroscopic (moisture-sensitive). Allow the vial to equilibrate to room temperature in a desiccator before opening to prevent condensation and hydrolysis. For long-term storage, consider under an inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white lyophilized powder
Identification (HPLC/MS)	Conforms to reference standard
Purity (HPLC)	≥ 95.0%
Single Impurity (HPLC)	≤ 1.0%
Peptide Content	≥ 80.0% (by amino acid analysis)
Water Content (KF)	≤ 5.0%
Acetate Content (HPLC)	≤ 10.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.