Description

4’-o-Desmethyl 4’-o-Acetyl Diltiazem is a key pharmaceutical intermediate and metabolite of the calcium channel blocker Diltiazem. This compound is of significant value in the research, development, and quality control of cardiovascular therapeutics. It is primarily required by pharmaceutical manufacturers, analytical laboratories, and research institutions engaged in drug metabolism studies, impurity profiling, and the synthesis of novel active pharmaceutical ingredients (APIs).

Application

• Pharmaceutical Intermediate: Critical for the synthesis and process development of Diltiazem and its related analogs.
• Reference Standard: Used as a certified reference material (CRM) for analytical method development and validation in HPLC, LC-MS, and GC-MS.
• Metabolite Studies: Essential for in-vitro and in-vivo pharmacokinetic and pharmacodynamic research to understand Diltiazem's metabolic pathways.
• Impurity Profiling: Serves as a known impurity standard to ensure the purity and safety of commercial Diltiazem API batches according to ICH guidelines.
• Bioanalytical Research: Employed in clinical and preclinical studies for the quantitative analysis of Diltiazem and its metabolites in biological matrices.
• Chemical Research: Used as a building block in medicinal chemistry for creating new chemical entities with potential therapeutic activity.

Basic Information

Product Name	4’-o-Desmethyl 4’-o-Acetyl Diltiazem
CAS No.	85365-35-1
Molecular Formula	C23H28N2O5S
Molecular Weight	444.55 g/mol
Synonyms	4'-O-Desmethyl-4'-O-acetyldiltiazem; 4'-O-Deacetyl-4'-O-methyldiltiazem (isomer); Diltiazem Impurity; Diltiazem Metabolite; (2S,3S)-5-[2-(Dimethylamino)ethyl]-2-(4-methoxyphenyl)-4-oxo-2,3,4,5-tetrahydro-1,5-benzothiazepin-3-yl acetate; N-Desmethyl Diltiazem Acetate; Diltiazem Related Compound; Contact for additional synonyms.
EINECS	Contact for details

Quality Control

Our 4’-o-Desmethyl 4’-o-Acetyl Diltiazem is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC for purity and identity confirmation via IR and MS, to ensure it meets high-purity standards suitable for pharmaceutical research. Certificates of Analysis (COA) with detailed chromatographic data are provided to support your regulatory and R&D requirements.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at controlled room temperature (15-25°C). The compound is light-sensitive; prolonged exposure should be avoided to maintain stability.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Purity (HPLC)	≥ 98.0%
Related Substances (HPLC)	Total impurities ≤ 2.0%
Single Maximum Unknown Impurity	≤ 0.5%
Residual Solvents (GC)	Complies with ICH Q3C
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.