Description

4-(Methylnitrosamino)-1-(3-Pyridyl-n-Oxide)-1-Butanol is a nitrosamine derivative and a key biomarker for tobacco-specific nitrosamine (TSNA) exposure. Its precise quantification is critical for toxicological research and public health studies related to smoking and smokeless tobacco products. This high-purity reference standard is essential for analytical laboratories, research institutions, and regulatory bodies focused on carcinogen monitoring and metabolic pathway analysis.

Application

• Biomarker Analysis: Primary metabolite used as a reference standard for quantifying NNK (4-(Methylnitrosamino)-1-(3-pyridyl)-1-butanone) exposure in biological matrices like urine and serum.
• Toxicological Research: Critical for studying the metabolic activation, DNA adduct formation, and carcinogenic mechanisms of tobacco-specific nitrosamines.
• Clinical Studies: Enables accurate assessment of tobacco smoke exposure and evaluation of smoking cessation interventions in epidemiological and clinical trials.
• Regulatory Compliance & Method Development: Used to develop and validate sensitive analytical methods (LC-MS/MS, GC-MS) for compliance testing in tobacco product regulation.
• Reference Material Production: Serves as a certified primary standard for the calibration of assays and the production of secondary quality control materials.
• Environmental & Occupational Health: Applied in research assessing secondhand smoke exposure and occupational risks in tobacco-related industries.

Basic Information

Item	Detail
Product Name	4-(Methylnitrosamino)-1-(3-Pyridyl-n-Oxide)-1-Butanol
CAS No.	85352-99-4
Molecular Formula	C10H15N3O2
Molecular Weight	209.25 g/mol
Synonyms	NNAL-N-oxide; 4-(Methylnitrosamino)-1-(3-pyridyl-N-oxide)-1-butanol; NNAL N-Oxide; 4-(N-Methyl-N-nitrosamino)-1-(3-pyridyl-N-oxide)-1-butanol; (RS)-4-(Methylnitrosamino)-1-(3-pyridyl-N-oxide)-1-butanol; 4-(Methylnitrosamino)-1-(3-pyridyl-1-oxide)-1-butanol; NNAL-O; Tobacco-specific nitrosamine metabolite NNAL-N-oxide
EINECS	Contact for details

Quality Control

Every batch of 4-(Methylnitrosamino)-1-(3-Pyridyl-n-Oxide)-1-Butanol is manufactured and tested under strict quality management systems. We provide comprehensive analytical data to ensure identity, purity, and stability, meeting the exacting requirements for high-purity reference standards. A detailed Certificate of Analysis (COA) is supplied with each shipment, documenting results from advanced analytical techniques including HPLC, MS, and NMR.

Storage

Preserve in a tightly closed container, protected from light. Store at controlled room temperature (15-25°C) or as indicated on the label or Certificate of Analysis. For long-term storage, consider storing at -20°C under inert atmosphere to ensure maximum stability.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Purity (HPLC)	≥ 98.0%
Related Substances (HPLC)	Total impurities ≤ 2.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.