Description

2,5-Difluorobenzamide is a high-purity fluorinated aromatic building block essential for advanced organic synthesis. This compound matters as a key intermediate in the development of active pharmaceutical ingredients (APIs) and agrochemicals, where its difluorobenzene core imparts desirable metabolic stability and lipophilicity. It is needed by R&D chemists and process development teams in the pharmaceutical, agrochemical, and specialty chemical industries for constructing complex molecules.

Application

• Pharmaceutical Intermediate: A critical precursor in the synthesis of novel drug candidates, particularly in kinase inhibitors and central nervous system (CNS) active compounds.
• Agrochemical Synthesis: Used in the development of next-generation herbicides and fungicides, leveraging the fluorine atoms to enhance biological activity and environmental persistence.
• Liquid Crystal & OLED Materials: Serves as a building block for fluorinated components in electronic display materials, contributing to improved performance and stability.
• Organic Synthesis Building Block: Employed in cross-coupling reactions (e.g., Suzuki, Buchwald-Hartwig) and amide bond transformations to introduce the 2,5-difluorophenyl moiety.
• Chemical Research & Development: Utilized in academic and industrial labs for method development and exploring new chemical entities.
• Material Science: A monomer or modifier in the synthesis of specialty polymers with tailored properties like chemical resistance and thermal stability.

Basic Information

Item	Detail
Product Name	2,5-Difluorobenzamide
CAS No.	85118-03-2
Molecular Formula	C7H5F2NO
Molecular Weight	157.12 g/mol
Synonyms	2,5-Difluorobenzamide; 2,5-Difluorobenzoic acid amide; Benzamide, 2,5-difluoro-; 85118-03-2; 2,5-Difluorobenzene-1-carboxamide; 2,5-Difluorophenylcarboxamide; 2,5-Difluorobenzoylamide; 2,5-Difluorobenzanilide (common misnomer)
EINECS	Contact for details

Quality Control

Our 2,5-Difluorobenzamide is manufactured under strict quality management systems. Every batch undergoes rigorous analytical testing, including HPLC for purity and identity confirmation by IR and NMR spectroscopy, to ensure it meets the high standards required for pharmaceutical and agrochemical applications. A comprehensive Certificate of Analysis (COA) detailing purity, assay, and impurity profiles is provided with each shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed after opening to prevent degradation from atmospheric moisture.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to reference spectrum
Purity (HPLC)	≥ 98.0%
Melting Point	142 - 147 °C
Loss on Drying	≤ 0.5%
Heavy Metals	≤ 20 ppm
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.