Description

3,5-Bis(Trifluoromethyl)Phenylacetonitrile is a versatile and high-value fluorinated aromatic nitrile building block. This compound is critical for introducing the highly lipophilic and electron-withdrawing bis(trifluoromethyl)phenyl moiety into advanced molecular architectures. It is primarily sought by R&D and production chemists in the pharmaceutical and agrochemical sectors for the synthesis of active ingredients and novel materials.

Application

• Pharmaceutical Intermediates: Key building block for the synthesis of active pharmaceutical ingredients (APIs), particularly in kinase inhibitors and other small molecule therapeutics.
• Agrochemical Synthesis: Used in the development of advanced herbicides, fungicides, and insecticides where the trifluoromethyl groups enhance biological activity and environmental stability.
• Ligand and Catalyst Development: Serves as a precursor for specialized phosphine and nitrogen-based ligands used in catalysis and material science.
• Functional Material Precursor: Employed in the research and production of liquid crystals, organic semiconductors, and polymers requiring specific electronic properties.
• Custom Synthesis & Contract Manufacturing: A high-purity starting material for custom synthesis projects and scale-up processes under cGMP or ISO standards.

Basic Information

Product Name	3,5-Bis(Trifluoromethyl)Phenylacetonitrile
CAS No.	85068-32-2
Molecular Formula	C10H5F6N
Molecular Weight	253.15 g/mol
Synonyms	2-[3,5-Bis(trifluoromethyl)phenyl]acetonitrile; (3,5-Bis(trifluoromethyl)phenyl)acetonitrile; α-Cyano-3,5-bis(trifluoromethyl)toluene; 3,5-Bis(trifluoromethyl)benzyl cyanide; 85068-32-2; 3,5-Di(trifluoromethyl)phenylacetonitrile
EINECS	Contact for details

Quality Control

Our production of 3,5-Bis(Trifluoromethyl)Phenylacetonitrile adheres to stringent quality management protocols. Each batch is fully characterized and tested to ensure identity, purity, and consistency. A comprehensive Certificate of Analysis (COA) detailing specifications such as assay (by HPLC), identity (IR, NMR), and impurity profiles is provided with every shipment to support your quality and regulatory requirements.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at room temperature (15-25°C). This material is hygroscopic (moisture-sensitive) and should be handled under dry conditions to prevent degradation. Keep away from strong acids and incompatible materials.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.