Description

Fmoc-His(3-Bom)-Oh is a protected derivative of the amino acid histidine, specifically engineered for solid-phase peptide synthesis (SPPS). This compound is critical for researchers and manufacturers requiring precise control over the imidazole side chain of histidine during complex peptide assembly. It is an essential building block for pharmaceutical R&D, particularly in the development of therapeutic peptides, diagnostic agents, and biochemical tools. The product is supplied to the highest purity standards to ensure optimal coupling efficiency and final product integrity.

Application

• Solid-Phase Peptide Synthesis (SPPS): A key protected amino acid for the automated, sequential synthesis of complex peptides and proteins.
• Pharmaceutical Research: Used in the discovery and development of novel peptide-based therapeutics, including hormones, antibiotics, and enzyme inhibitors.
• Bioconjugation: Serves as a specialized intermediate for creating peptide-protein or peptide-small molecule conjugates for targeted drug delivery.
• Combinatorial Chemistry: Employed in libraries for high-throughput screening to identify new bioactive compounds.
• Academic & Industrial R&D: Fundamental reagent for biochemical studies involving histidine's role in catalysis and metal binding within peptides.
• Production of Custom Peptides: Used by CROs and CDMOs for the reliable, gram-to-kilogram scale production of bespoke peptide sequences for clients.

Basic Information

Product Name	Fmoc-His(3-Bom)-Oh
CAS No.	84891-19-0
Molecular Formula	C27H27N3O6
Molecular Weight	489.52 g/mol
Synonyms	Fmoc-His(Bom)-OH; N-α-Fmoc-N-π-Bom-L-histidine; Fmoc-L-histidine(N-π-Bom)-OH; (S)-2-(((9H-Fluoren-9-yl)methoxy)carbonylamino)-3-(1-(benzyloxymethyl)-1H-imidazol-4-yl)propanoic acid; Fmoc-His(Bzl-OMe)-OH (common abbreviation); Nα-Fmoc-Nim-Bom-L-histidine; Fmoc-His(3-Benzyloxymethyl)-OH; Fmoc-His(Bom)
EINECS	Contact for details

Quality Control

Our Fmoc-His(3-Bom)-Oh is manufactured under strict quality management systems to ensure batch-to-batch consistency and high purity, typically exceeding 98.5% (HPLC). Each lot is accompanied by a comprehensive Certificate of Analysis (COA) detailing purity, chiral integrity, and impurity profiles. We adhere to cGMP guidelines where applicable, supporting its use in regulated research and pre-clinical development phases.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below under desiccant for long-term stability. This material is hygroscopic (moisture-sensitive); allow the sealed container to equilibrate to room temperature before opening to prevent condensation. For short-term use (up to one month), storage at 2-8°C is acceptable.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (HPLC)	Conforms to reference standard
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 98.5%
Optical Rotation [α]D20	-10.0° to -14.0° (c=1 in DMF)
Water Content (KF)	≤ 0.5%
Heavy Metals	≤ 10 ppm
Residual Solvents (GC)	Complies with ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.