Description

(5Alpha,6Alpha)-4,5-Epoxy-3-Methoxy-17-Methylmorphinan-6-Yl Thiocyanate is a high-purity, specialized morphinan derivative of significant interest in advanced pharmaceutical research and development. This compound serves as a critical synthetic intermediate or reference standard for the study of opioid receptor activity and the development of novel therapeutic agents. It is primarily utilized by research institutions, pharmaceutical R&D laboratories, and fine chemical manufacturers engaged in neuropharmacology and medicinal chemistry. The precise stereochemistry and functional groups make it a valuable building block for creating targeted molecular libraries.

Application

• Pharmaceutical Intermediate: Key precursor in the multi-step synthesis of novel opioid analgesics or antagonists with modified pharmacological profiles.
• Reference Standard: Used in analytical laboratories for method development, validation, and quality control of related active pharmaceutical ingredients (APIs).
• Medicinal Chemistry Research: Employed in structure-activity relationship (SAR) studies to explore the impact of the thiocyanate moiety on receptor binding affinity and selectivity.
• Biochemical Tool Compound: Utilized in *in vitro* assays to investigate opioid receptor signaling pathways and mechanisms of action.
• Process Chemistry Development: Serves as a model compound for scaling up and optimizing synthetic routes for complex morphinan-based molecules.

Basic Information

Product Name	(5Alpha,6Alpha)-4,5-Epoxy-3-Methoxy-17-Methylmorphinan-6-Yl Thiocyanate
CAS No.	84824-87-3
Molecular Formula	C20H24N2O2S
Molecular Weight	356.48 g/mol
Synonyms	6-Thiocyanato-4,5-epoxy-3-methoxy-17-methylmorphinan; 6-Thiocyanatonaltrexone; 6-Thiocyanato-naltrexone; (5α,6α)-6-Thiocyanato-4,5-epoxy-3-methoxy-17-methylmorphinan; Naltrexone 6-thiocyanate; 17-Methyl-4,5α-epoxy-3,14-dihydroxymorphinan-6α-thiocyanate (deprotected form reference); Morphinan-6-ol, 4,5-epoxy-3-methoxy-17-methyl-, 6-thiocyanate, (5α,6α)-
EINECS	Contact for details

Quality Control

Our (5Alpha,6Alpha)-4,5-Epoxy-3-Methoxy-17-Methylmorphinan-6-Yl Thiocyanate is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity, NMR and IR for structural confirmation, and residual solvent analysis, to ensure it meets the stringent requirements for research and development use. Certificates of Analysis (COA) detailing all test results are provided with every shipment to guarantee traceability and compliance with your specifications.

Storage

Preserve in a tightly closed container, protected from light. Store at controlled room temperature (15-25°C) in a dry, well-ventilated area. The compound is light-sensitive; prolonged exposure to light should be avoided to maintain stability.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Purity (HPLC)	≥ 98.0%
Related Substances (HPLC)	Individual impurity ≤ 0.5% Total impurities ≤ 2.0%
Residual Solvents (GC)	Meets ICH Q3C guidelines
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.