Description

16-Fluoroestradiol is a fluorinated derivative of the natural hormone estradiol, designed to enhance metabolic stability and receptor binding affinity. This compound is a critical intermediate and reference standard in the development of diagnostic and therapeutic radiopharmaceuticals. It is primarily utilized by research institutions and pharmaceutical companies engaged in oncology research, particularly for the imaging and treatment of estrogen receptor-positive cancers.

Application

• Radiopharmaceutical Precursor: Acts as a key starting material for the synthesis of fluorine-18 labeled tracers, such as [18F]Fluoroestradiol (FES), used in Positron Emission Tomography (PET) imaging.
• Oncology Research: Serves as a non-radioactive reference standard in the development and validation of assays for detecting and quantifying estrogen receptor (ER) expression in tumors.
• Biochemical Research: Used as a high-affinity ligand in receptor binding studies to investigate ERα and ERβ subtype selectivity and function.
• Drug Development: Employed as a model compound to study the structure-activity relationships (SAR) of steroidal molecules and to develop novel ER-targeted therapies.
• Quality Control: Functions as a certified reference material (CRM) for calibrating analytical equipment and ensuring the purity and identity of radioactive pharmaceutical batches.

Basic Information

Product Name	16-Fluoroestradiol
CAS No.	84693-92-5
Molecular Formula	C18H23FO2
Molecular Weight	290.37 g/mol
Synonyms	16α-Fluoroestradiol; 16α-Fluoro-1,3,5(10)-estratriene-3,17β-diol; Estra-1,3,5(10)-triene-3,17-diol, 16-fluoro-, (16α,17β)-; 16-Fluoro-17β-estradiol; FES Precursor; Fluorinated Estradiol
EINECS	Contact for details

Quality Control

Every batch of 16-Fluoroestradiol is manufactured and tested under strict quality management systems. We provide comprehensive analytical data to support its use in regulated environments. Our products undergo rigorous quality testing to ensure compliance with industry standards. Certificates of Analysis (COA) are available upon request, detailing purity, identity, and impurity profiles as determined by advanced chromatographic and spectroscopic methods.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This material is hygroscopic (moisture-sensitive) and should be handled under anhydrous conditions to maintain stability and purity. For long-term storage, consider desiccated or inert atmosphere conditions.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to reference spectrum
Identification (HPLC)	Retention time matches reference standard
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Specific Rotation	Contact for details

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.