Description

(+/-)-Didesmethylsibutramine CAS NO 84467-54-9 is a key pharmaceutical intermediate and metabolite of sibutramine, a compound of significant interest in medicinal chemistry research. Its primary value lies in its role as a critical reference standard and building block for the development and analytical validation of therapeutic agents targeting the central nervous system. This compound is essential for pharmaceutical R&D laboratories, analytical testing facilities, and manufacturers specializing in active pharmaceutical ingredients (APIs) and high-purity fine chemicals.

Application

• Pharmaceutical Reference Standard: Critical for the identification, purity assessment, and quantification of sibutramine and its metabolites in drug development and quality control (QC) laboratories.
• Metabolite Studies: Used in pharmacokinetic and pharmacodynamic research to understand the metabolic pathway, bioavailability, and clearance of sibutramine.
• Analytical Method Development: Serves as a certified standard for calibrating and validating analytical methods such as HPLC, LC-MS, and GC-MS in compliance with GLP and GMP guidelines.
• Impurity Profiling: Employed to identify, characterize, and control related substance impurities during the synthesis and purification of sibutramine hydrochloride API.
• Biomedical Research: Utilized as a tool compound in preclinical studies investigating neurotransmitter reuptake inhibition mechanisms.
• Custom Synthesis: Acts as a sophisticated starting material or intermediate for the synthesis of novel chemical entities and labeled analogs for tracer studies.

Basic Information

Product Name	(+/-)-Didesmethylsibutramine
CAS No.	84467-54-9
Molecular Formula	C15H22ClN
Molecular Weight	251.80 g/mol
Synonyms	N-{1-[1-(4-Chlorophenyl)cyclobutyl]-3-methylbutyl}-N-methylamine; BTS 54 505; Desmethylsibutramine; Didesmethyl Sibutramine; 1-(4-Chlorophenyl)-N,N-dimethyl-α-isobutylcyclobutanemethylamine; 1-[1-(4-Chlorophenyl)cyclobutyl]-3-methyl-N-methyl-1-butylamine
EINECS	Contact for details

Quality Control

Our (+/-)-Didesmethylsibutramine is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including identification by spectroscopic methods (IR, NMR), purity determination by HPLC, and control of specified impurities. A Certificate of Analysis (COA) detailing batch-specific results is provided with every shipment, ensuring traceability and compliance with research and pharmaceutical industry standards.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at controlled room temperature (15-25°C). This compound is hygroscopic (moisture-sensitive); therefore, the container must be kept tightly sealed in a dry environment to prevent degradation. For long-term storage, consider desiccants or inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to reference spectrum
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥ 98.0%
Related Substances (HPLC)	Total impurities ≤ 2.0% Any single unknown impurity ≤ 0.5%
Residual Solvents (GC)	Complies with ICH Q3C guidelines
Loss on Drying	≤ 1.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.