Description

3'-o-(5-Azidonaphthoyl)Adenosine Diphosphate is a specialized, photoactivatable nucleotide derivative designed for cross-linking studies. This compound matters for researchers requiring precise, covalent labeling of nucleotide-binding sites within proteins and enzymes. It is primarily needed by scientists in biochemistry, enzymology, and structural biology for affinity labeling, mapping active sites, and investigating protein-nucleotide interactions.

Application

• Affinity Labeling of Enzymes: Covalent modification of ATP/GTP-binding proteins and kinases for functional studies.
• Active Site Mapping: Identification and characterization of nucleotide-binding pockets in proteins and receptors.
• Photoaffinity Labeling Probes: Used as a critical reagent in photochemical cross-linking experiments to study transient biomolecular interactions.
• Bioconjugation and Probe Development: Serves as a precursor for synthesizing advanced molecular probes and diagnostic tools.
• Structural Biology Research: Aids in the elucidation of three-dimensional structures and interaction networks involving nucleotides.
• Drug Discovery Target Validation: Used to validate and characterize potential drug targets that interact with adenosine diphosphate.

Basic Information

Product Name	3'-o-(5-Azidonaphthoyl)Adenosine Diphosphate
CAS No.	84453-67-8
Molecular Formula	C26H25N9O13P2
Molecular Weight	733.49 g/mol
Synonyms	3'-O-[5-(Azido)-1-naphthoyl]adenosine 5'-diphosphate; 5'-ADP-3'-(5-azidonaphthoate); 3'-O-(5-Azidonaphthoyl)-ADP; Naphthoylazido ADP; Photoaffinity ADP analog; Adenosine 5'-diphosphate, 3'-(5-azido-1-naphthoate); Azido-NAP-ADP; 5-Azidonaphthoyl-ADP
EINECS	Contact for details

Quality Control

Our 3'-o-(5-Azidonaphthoyl)Adenosine Diphosphate is produced under stringent conditions to ensure high purity and batch-to-batch consistency, suitable for sensitive research applications. Each lot undergoes comprehensive analytical characterization, including HPLC for purity and spectroscopic methods for structural confirmation. Certificates of Analysis (COA) detailing purity, identity, and other critical parameters are available upon request to support your quality assurance protocols.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below in a dry environment. This product is hygroscopic (moisture-sensitive) and light-sensitive. For long-term storage, keep desiccated and under inert atmosphere if possible. Allow the vial to equilibrate to room temperature before opening to minimize moisture condensation.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (HPLC)	Conforms to reference standard
Identification (MS)	Conforms to structure
Purity (HPLC)	≥ 95%
Water Content (KF)	≤ 2.0%
Solubility	Soluble in DMSO, DMF; sparingly soluble in aqueous buffers

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.