Description

n-Hydroxypropranolol is a key metabolite and synthetic intermediate of the widely used β-blocker, propranolol. This compound is of significant value for pharmaceutical research and development, particularly in metabolic and pharmacokinetic studies. It serves as a critical reference standard and building block for scientists and manufacturers in the pharmaceutical, analytical, and life science sectors.

Application

• Pharmaceutical Reference Standard: Used as a certified reference material (CRM) for the quantification and qualification of propranolol and its metabolites in analytical methods.
• Metabolite Research: Essential for studying the metabolic pathways, bioavailability, and clearance mechanisms of propranolol in preclinical and clinical research.
• Active Pharmaceutical Ingredient (API) Synthesis: Serves as a crucial synthetic intermediate in the development and production of novel β-adrenergic blocking agents and related derivatives.
• Analytical Method Development: Employed in the development and validation of HPLC, LC-MS, and other chromatographic assays for drug testing and bioanalysis.
• Biochemical Research: Used in enzymatic and receptor-binding studies to investigate the pharmacological activity and selectivity of β-blocker metabolites.
• Quality Control & Assurance: Acts as an impurity standard to monitor and control the quality of propranolol API and finished drug products during manufacturing.

Basic Information

Product Name	n-Hydroxypropranolol
CAS No.	84418-31-5
Molecular Formula	C16H21NO3
Molecular Weight	275.35 g/mol
Synonyms	4'-Hydroxypropranolol; 1-(Isopropylamino)-3-(4-hydroxyphenoxy)-2-propanol; 4-Hydroxypropranolol; Propranolol, 4'-hydroxy-; Propranolol Metabolite; 1-(Isopropylamino)-3-(p-hydroxyphenoxy)-2-propanol; 3-(4-Hydroxyphenoxy)-1-(isopropylamino)-2-propanol; (±)-4'-Hydroxypropranolol
EINECS	Contact for details

Quality Control

Our n-Hydroxypropranolol is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity and identity confirmation (IR, NMR), to ensure it meets high-purity standards suitable for research and development. Certificates of Analysis (COA) with detailed chromatographic data are provided to guarantee traceability and batch-to-batch consistency.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at controlled room temperature (15-25°C). The product is light-sensitive and should be handled accordingly to maintain stability.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.