Description

Lorazepam-D4 is a stable isotope-labeled analog of the widely used benzodiazepine, Lorazepam, where four hydrogen atoms are replaced by deuterium. This high-purity reference standard is essential for ensuring the accuracy and reliability of quantitative analytical methods. It is primarily utilized by pharmaceutical R&D laboratories, contract research organizations (CROs), and forensic and clinical toxicology departments for applications requiring precise internal standardization. The compound's labeled structure provides a critical tool for method development and validation in complex matrices.

Application

• Internal Standard for LC-MS/MS and GC-MS: Serves as a critical quantitative reference in mass spectrometry-based bioanalysis for drug metabolism and pharmacokinetic (DMPK) studies.
• Pharmaceutical Impurity Profiling and Assay Development: Used in the development and validation of analytical methods to quantify Lorazepam and related substances in active pharmaceutical ingredients (APIs) and finished dosage forms.
• Forensic and Clinical Toxicology: Enables accurate quantification of Lorazepam in biological samples (e.g., blood, urine) for medical-legal investigations and therapeutic drug monitoring.
• Metabolite Identification and Pathway Studies: Aids in the identification and quantification of Lorazepam metabolites in in vitro and in vivo studies due to its distinct mass shift.
• Quality Control and Compliance Testing: Supports compliance with regulatory guidelines (e.g., FDA, EMA) by providing a traceable standard for method qualification and routine QC testing in pharmaceutical manufacturing.

Basic Information

Product Name	Lorazepam-D4
CAS No.	84344-15-0
Molecular Formula	C15H10D4Cl2N2O2
Molecular Weight	325.20 g/mol
Synonyms	7-Chloro-5-(2-chlorophenyl)-1,3-dihydro-1,1,2,2-tetradeuterio-3-hydroxy-2H-1,4-benzodiazepin-2-one; Lorazepam (phenyl-d4); [2H4]-Lorazepam; Lorazepam-d4; Deuterated Lorazepam; Ativan-d4; Temesta-d4
EINECS	Contact for details

Quality Control

Our Lorazepam-D4 is manufactured under strict quality systems to ensure the highest standards of isotopic purity and chemical integrity. Each batch undergoes comprehensive analytical characterization, including NMR, HPLC, and mass spectrometry, to confirm identity, chemical purity, and isotopic enrichment. A detailed Certificate of Analysis (COA) is provided with each shipment, documenting all critical quality attributes. Our commitment to cGMP principles and traceability ensures the material is suitable for demanding regulatory applications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This material is hygroscopic (moisture-sensitive); ensure the container is sealed tightly after each use to minimize exposure to atmospheric humidity. For long-term storage, consider storing under an inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to reference spectrum
Identification (MS)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Isotopic Purity (Deuterium Content)	≥ 98 atom % D
Chemical Purity (by HPLC)	≥ 99.0%
Residual Solvents (GC)	Complies with ICH guidelines
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.