Description

N,n-Didesmethyl Trimebutine is a key pharmaceutical intermediate and metabolite of the gastrointestinal drug Trimebutine. This compound is of significant value for research and development in the synthesis of advanced active pharmaceutical ingredients (APIs) targeting functional gastrointestinal disorders. It is primarily required by pharmaceutical manufacturers, contract research organizations (CROs), and analytical laboratories engaged in drug development, metabolite studies, and quality control processes.

Application

• Pharmaceutical Intermediate: Critical building block in the synthesis of Trimebutine and its related analogs.
• Reference Standard: Used as a high-purity standard in analytical methods (HPLC, LC-MS) for drug substance and product testing.
• Metabolite Studies: Essential for pharmacokinetic and pharmacodynamic research to understand the drug's metabolism and activity.
• Process Development: Employed in the development and optimization of scalable API manufacturing processes.
• Impurity Profiling: Serves as a known impurity or degradation product reference in stability studies and regulatory filings.
• Biomedical Research: Utilized in preclinical studies to investigate mechanisms of action related to gastrointestinal motility.

Basic Information

Product Name	N,n-Didesmethyl Trimebutine
CAS No.	84333-60-8
Molecular Formula	C20H31NO5
Molecular Weight	365.47 g/mol
Synonyms	3,4,5-Trimethoxybenzoic acid 2-(dimethylamino)-2-phenylbutyl ester; Trimebutine metabolite; N,N-Didesmethyltrimebutine; 2-Phenyl-2-(dimethylamino)butyl 3,4,5-trimethoxybenzoate; Deaminated Trimebutine derivative; (2-Phenyl-2-(dimethylamino)butyl) 3,4,5-trimethoxybenzoate
EINECS	Contact for details

Quality Control

Our N,n-Didesmethyl Trimebutine is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including identification, assay, and impurity profiling by HPLC and other validated methods, to ensure it meets stringent specifications for pharmaceutical research use. Certificates of Analysis (COA) with detailed chromatographic data are provided to guarantee traceability, purity, and batch-to-batch consistency.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at controlled room temperature (15-25°C). Due to its hygroscopic nature, the container must be kept tightly sealed in a dry environment to prevent moisture absorption.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to reference spectrum
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥ 98.0%
Related Substances (HPLC)	Total impurities ≤ 2.0% Any single unknown impurity ≤ 0.5%
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.