Description

H-D-Phe-Met-Arg-Phe-Nh2 is a synthetic pentapeptide amide, a potent and selective ligand for neuropeptide FF (NPFF) receptors. This compound matters as a critical research tool for studying the NPFF system, which is involved in modulating pain perception, opioid tolerance, and cardiovascular functions. It is primarily needed by pharmaceutical R&D teams, academic neuroscientists, and biochemical suppliers focused on neuropharmacology and central nervous system drug discovery.

Application

• Neuroscience Research: As a standard NPFF receptor agonist for investigating pain modulation pathways and opioid-induced hyperalgesia.
• Pharmacological Studies: For in vitro and in vivo assays to characterize receptor binding affinity, selectivity, and functional activity.
• Drug Discovery: Serving as a reference compound or a starting point for the development of novel analgesics and neuropsychiatric therapeutics.
• Biochemical Reagent: Used in the preparation of calibration standards and controls in analytical method development for peptide quantification.
• Academic & Institutional Labs: Fundamental research into the physiological roles of NPFF and related peptides.

Basic Information

Product Name	H-D-Phe-Met-Arg-Phe-Nh2
CAS No.	84313-42-8
Molecular Formula	C34H50N10O5S
Molecular Weight	710.89 g/mol
Synonyms	FMRFamide; Phe-Met-Arg-Phe-NH2; Neuropeptide FF (NPFF); H-Phe-Met-Arg-Phe-NH2; F8Famide; FLFQPQRF-NH2 related peptide; Mammalian FMRFamide-like peptide; 84313-42-8
EINECS	Contact for details

Quality Control

Our H-D-Phe-Met-Arg-Phe-Nh2 is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity, MS for identity confirmation, and amino acid analysis. Certificates of Analysis (COA) detailing purity, peptide content, and solvent residues are provided to ensure compliance with research-grade standards and support reproducible scientific results.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below in a dry environment. This product is hygroscopic (moisture-sensitive). Allow the vial to equilibrate to room temperature in a desiccator before opening to minimize moisture uptake.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (HPLC/MS)	Conforms to reference standard
Purity (HPLC)	≥ 95.0%
Peptide Content	≥ 80.0%
Single Impurity (HPLC)	≤ 1.0%
Amino Acid Analysis	Within ± 10% of theoretical
Water Content (KF)	≤ 5.0%
Acetate Content (HPLC)	≤ 10.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.