Description

4'-Benzyloxyphenyl Acetylene is a high-purity organic building block featuring a terminal alkyne group protected by a benzyloxy moiety. This compound matters as a versatile and reactive intermediate, enabling the synthesis of complex molecular architectures through cross-coupling and cycloaddition reactions. It is primarily needed by pharmaceutical R&D teams and fine chemical manufacturers for applications in drug discovery, material science, and advanced organic synthesis.

Application

• Pharmaceutical Intermediate: A key synthon in the synthesis of active pharmaceutical ingredients (APIs) and drug candidates, particularly for kinase inhibitors and other small molecule therapeutics.
• Material Science Research: Used in the development of organic semiconductors, liquid crystals, and advanced polymers via Sonogashira and other palladium-catalyzed coupling reactions.
• Agrochemical Synthesis: Serves as a building block for creating novel crop protection agents and herbicides with tailored properties.
• Academic & Industrial R&D: Employed in medicinal chemistry and chemical biology for library synthesis, probe development, and structure-activity relationship (SAR) studies.
• Ligand and Catalyst Preparation: Useful for constructing complex ligand frameworks for transition metal catalysts used in asymmetric synthesis.

Basic Information

Product Name	4'-Benzyloxyphenyl Acetylene
CAS No.	84284-70-8
Molecular Formula	C15H12O
Molecular Weight	208.26 g/mol
Synonyms	1-(Benzyloxy)-4-ethynylbenzene; 4-Ethynylphenyl benzyl ether; 4-(Benzyloxy)phenylacetylene; p-(Benzyloxy)phenylacetylene; 4-Benzyloxyphenylacetylene; 1-Ethynyl-4-(phenylmethoxy)benzene; (4-(Benzyloxy)phenyl)ethyne
EINECS	Contact for details

Quality Control

Our 4'-Benzyloxyphenyl Acetylene is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, GC, and NMR, to ensure high chemical purity and identity confirmation. Certificates of Analysis (COA) detailing all specifications are provided with every shipment to guarantee traceability and compliance with your research or production standards.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at room temperature (15-25°C). This product is hygroscopic (moisture-sensitive); keep the container tightly sealed under an inert atmosphere (e.g., nitrogen or argon) for long-term storage to prevent degradation.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Melting Point	Contact for details
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.