Description

Doxifluridine-D2 is a deuterated analog of the antineoplastic agent doxifluridine, specifically designed for advanced pharmaceutical research and development. This compound is crucial for conducting mass spectrometry-based studies, including ADME (Absorption, Distribution, Metabolism, and Excretion) and pharmacokinetic research, where its stable isotope labeling provides an essential internal standard. It is primarily utilized by pharmaceutical companies, contract research organizations (CROs), and academic institutions engaged in oncology drug discovery and metabolic pathway analysis.

Application

• Internal standard for the quantitative bioanalysis of doxifluridine and its metabolites using LC-MS/MS and GC-MS techniques.
• Critical reagent in drug metabolism and pharmacokinetics (DMPK) studies to track the fate of the parent drug in biological systems.
• Use in proteomics and metabolomics research to investigate cellular responses and metabolic pathways in cancer models.
• Development and validation of sensitive analytical methods for therapeutic drug monitoring (TDM) in clinical research settings.
• Supporting regulatory submissions by providing definitive data on drug exposure and metabolic stability.
• Chemical reference standard for quality control and impurity profiling in the manufacturing of active pharmaceutical ingredients (APIs).

Basic Information

Product Name	Doxifluridine-D2
CAS No.	84258-25-3
Molecular Formula	C9H9D2FN2O5
Molecular Weight	247.19 g/mol (for monoisotopic mass)
Synonyms	5'-Deoxy-5-fluorouridine-d2; 5'-DFUR-D2; Furtulon-D2; Ro 21-9738-D2; 1-((2R,4S,5R)-4-Hydroxy-5-(hydroxymethyl)tetrahydrofuran-2-yl)-5-fluoro-2,4(1H,3H)-pyrimidinedione-d2; 5-Fluoro-5'-deoxyuridine-d2; 5-FUDR-D2
EINECS	Contact for details

Quality Control

Our Doxifluridine-D2 is produced under strict quality management systems to ensure the highest standards of isotopic purity and chemical integrity. Each batch is characterized by advanced analytical techniques including NMR, HPLC, and mass spectrometry to confirm deuterium incorporation and chemical purity. A comprehensive Certificate of Analysis (COA) detailing isotopic enrichment, chemical purity, and analytical results is provided with every shipment to support your critical research and regulatory needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and should be handled in a dry environment to prevent degradation. For long-term storage, consider desiccated conditions.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Identification (MS)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Isotopic Purity (D-content)	≥ 98.0 atom % D
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.