Description

Parathyroid Hormone (46-84) is a specific, biologically active fragment of the full-length parathyroid hormone (PTH). This high-purity peptide is critical for research into calcium metabolism, bone physiology, and endocrine signaling pathways. It is primarily utilized by pharmaceutical R&D teams, academic research institutions, and diagnostic manufacturers focused on metabolic bone diseases and hormone receptor studies.

Application

• Biomedical Research: Used as a key reagent in studying the structure-activity relationship of PTH, its receptor binding mechanisms, and downstream signaling cascades.
• Pharmaceutical Development: Serves as a reference standard and intermediate in the development of novel therapeutics for osteoporosis, hypoparathyroidism, and other bone mineral disorders.
• Diagnostic Assays: Employed in the calibration and validation of immunoassays and bioassays designed to measure PTH levels or activity in clinical samples.
• Cell Biology Studies: Applied in in vitro cell culture models to investigate the effects of PTH on osteoblast and osteoclast activity and bone remodeling.
• Biochemical Standard: Acts as a purified standard for quality control in peptide synthesis and for comparative analysis in chromatographic and spectroscopic studies.

Basic Information

Product Name	Parathyroid Hormone (46-84)
CAS No.	84069-06-7
Molecular Formula	C185H294N55O51S2
Molecular Weight	~4240.8 g/mol
Synonyms	PTH (46-84); Parathyroid Hormone Fragment 46-84; Human Parathyroid Hormone (46-84); hPTH (46-84); Parathyrin (46-84); PTH 46-84; CAS 84069-06-7; Parathyroid Hormone, Human, 46-84
EINECS	Contact for details

Quality Control

Our Parathyroid Hormone (46-84) is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity, MS for identity confirmation, and amino acid analysis. A Certificate of Analysis (COA) detailing purity, peptide content, and endotoxin levels is provided with every shipment to ensure it meets the stringent requirements of research and development applications.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below in a dry environment. This product is hygroscopic (moisture-sensitive). Allow the vial to equilibrate to room temperature in a desiccator before opening to minimize moisture absorption.

Specification

Item	Specification
Appearance	White to off-white lyophilized powder
Identification (HPLC/MS)	Conforms to reference standard
Purity (HPLC)	≥ 95.0%
Peptide Content	≥ 80.0% (by weight)
Amino Acid Composition	Within ±10% of theoretical
Water Content (KF)	≤ 5.0%
Acetate Content (HPLC)	≤ 10.0%
Endotoxin	< 10 EU/mg

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.