Description

Complement Complex C5B-7 is a defined biological reagent complex, specifically associated with the complement system cascade. This product is critical for research and development in immunology and biochemistry, providing a standardized component for studying immune response pathways. It is primarily utilized by pharmaceutical R&D teams, diagnostic manufacturers, and academic research institutions focusing on autoimmune diseases, inflammation, and therapeutic antibody development.

Application

• Immunological Research: Used as a key reagent in in vitro studies of the classical and alternative complement pathways.
• Diagnostic Assay Development: Serves as a critical component in the formulation of kits for detecting complement activity or deficiencies.
• Biopharmaceutical Testing: Employed in quality control and functional assays for therapeutic antibodies, especially those that modulate the complement system (e.g., C5 inhibitors).
• Drug Discovery Screening: Used in high-throughput screening platforms to identify novel compounds that target complement-mediated diseases.
• Biomarker Studies: Facilitates research into the role of complement activation in various disease states, including sepsis, age-related macular degeneration (AMD), and neurological disorders.

Basic Information

Product Name	Complement Complex C5B-7
CAS No.	84012-72-6
Molecular Formula	Contact for details
Molecular Weight	Contact for details
Synonyms	C5b-7 Complex; Terminal Complement Complex C5b-7; Membrane Attack Complex Precursor C5b-7; Complement Component Complex C5b-7; C5b6-7 Complex; Complement Activation Product C5b-7; MAC Precursor C5b-7
EINECS	Contact for details

Quality Control

Our Complement Complex C5B-7 is produced under stringent conditions to ensure biological activity and batch-to-batch consistency. Each lot undergoes rigorous functional and purity testing, including activity assays, SDS-PAGE analysis, and endotoxin level verification. Certificates of Analysis (COA) detailing all specifications and test results are provided to ensure compliance with research-grade standards.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below for long-term stability. Avoid repeated freeze-thaw cycles. This material is easily oxidized; aliquoting under an inert atmosphere is recommended for optimal preservation of activity.

Specification

Item	Specification
Appearance	Clear to slightly opalescent solution
Identification (Functional Assay)	Confirms specific complement pathway activity
Purity (SDS-PAGE)	≥ 90% (Reduced)
Protein Concentration	Specified on COA
Biological Activity	Specified on COA
Endotoxin	< 1.0 EU/mg
Buffer Composition	Specified on COA

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.