Description

Fmoc-N-Me-Val-OH is a high-purity, protected amino acid derivative essential for modern peptide synthesis. This compound serves as a critical building block, enabling the controlled introduction of N-methylated valine residues into peptide chains, which can enhance metabolic stability and bioavailability. It is primarily utilized by research institutions and pharmaceutical companies engaged in the development of novel therapeutic peptides, peptidomimetics, and bioactive compounds.

Application

• Solid-Phase Peptide Synthesis (SPPS): A key reagent for the sequential assembly of peptides using Fmoc-chemistry protocols.
• Peptidomimetic Drug Discovery: Used to incorporate N-methyl amino acids into peptide backbones to improve drug-like properties such as membrane permeability and proteolytic resistance.
• Combinatorial Chemistry Libraries: Serves as a valuable monomer for generating diverse libraries of peptide-based compounds for high-throughput screening.
• Bioconjugation and Probe Development: Facilitates the site-specific modification of peptides with labels, tags, or other functional groups for diagnostic and research applications.
• Academic and Industrial Research: Employed in fundamental studies of peptide structure-activity relationships (SAR) and protein-protein interactions.

Basic Information

Product Name	Fmoc-N-Me-Val-OH
CAS No.	84000-11-3
Molecular Formula	C₂₁H₂₃NO₄
Molecular Weight	353.41 g/mol
Synonyms	Fmoc-N-methyl-L-valine; (2S)-2-[(9H-Fluoren-9-ylmethoxy)carbonyl(methyl)amino]-3-methylbutanoic acid; N-[(9H-Fluoren-9-ylmethoxy)carbonyl]-N-methyl-L-valine; Fmoc-N-Me-Valine; Fmoc-N-Methylvaline; Nα-Fmoc-N-methyl-L-valine; N-Fmoc-N-methyl-L-valine
EINECS	Contact for details

Quality Control

Our Fmoc-N-Me-Val-OH is manufactured under strict quality management systems to ensure batch-to-batch consistency and high purity, suitable for sensitive research and development applications. Each lot is accompanied by a comprehensive Certificate of Analysis (COA) detailing purity, identity, and impurity profiles. We adhere to relevant industry standards and can provide material tailored to specific project requirements.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 15-25°C. This material is hygroscopic (moisture-sensitive) and should be handled in a dry environment to prevent degradation. For long-term storage, consider desiccation.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Conforms to reference
Assay (HPLC)	≥98.0%
Specific Rotation	Contact for details
Water Content (KF)	≤1.0%
Heavy Metals	≤20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.