Description

Nalpha-9-Fluorenylmethoxycarbonyl-L-Pipecolinic Acid is a protected amino acid derivative, specifically an Fmoc-protected cyclic amino acid building block. This compound is essential for the solid-phase peptide synthesis (SPPS) of peptides containing the non-proteinogenic amino acid L-pipecolic acid, enabling the creation of complex peptide architectures. It is a critical raw material for pharmaceutical R&D, particularly in the development of peptide-based therapeutics, diagnostic agents, and bioactive probes.

Application

• Solid-Phase Peptide Synthesis (SPPS): A key building block for the automated synthesis of peptides incorporating L-pipecolic acid residues.
• Pharmaceutical Research & Development: Used in the discovery and development of novel peptide drugs targeting GPCRs, enzymes, and other biological pathways.
• Peptidomimetic Design: Serves as a precursor for creating conformationally constrained peptidomimetics to enhance metabolic stability and binding affinity.
• Combinatorial Chemistry Libraries: A valuable component for generating diverse peptide libraries for high-throughput screening.
• Bioconjugation & Probe Development: Utilized in the synthesis of labeled peptides for imaging, diagnostics, and biochemical assays.
• Academic & Institutional Research: Employed in biochemistry and medicinal chemistry laboratories for studying protein-protein interactions and peptide structure-activity relationships.

Basic Information

Product Name	Nalpha-9-Fluorenylmethoxycarbonyl-L-Pipecolinic Acid
CAS No.	84000-01-1
Molecular Formula	C22H23NO4
Molecular Weight	365.42 g/mol
Synonyms	Fmoc-L-Pipecolic Acid; Fmoc-Pip-OH; N-[(9H-Fluoren-9-ylmethoxy)carbonyl]-L-pipecolic Acid; (S)-1-((((9H-Fluoren-9-yl)methoxy)carbonyl)piperidine-2-carboxylic acid; Fmoc-L-Homopro-OH; N-Fmoc-L-pipecolinic acid; N-α-Fmoc-L-pipecolic acid; L-Pipecolic acid, N-[(9H-fluoren-9-ylmethoxy)carbonyl]-
EINECS	Contact for details

Quality Control

Our Nalpha-9-Fluorenylmethoxycarbonyl-L-Pipecolinic Acid is manufactured under strict quality systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity and chiral purity verification, to ensure it meets the stringent requirements of peptide synthesis. Certificates of Analysis (COA) with detailed chromatographic data are provided for every shipment, supporting cGMP-compliant research and development workflows.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 15-25°C. This material is hygroscopic (moisture-sensitive); keep the container tightly sealed in a desiccated environment to maintain stability and prevent degradation.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (HPLC)	Conforms
Identification (IR)	Conforms
Assay (HPLC)	≥98.0%
Chiral Purity (HPLC)	≥99.0%
Water Content (KF)	≤0.5%
Heavy Metals	≤10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.