Description

(2S)-3-[1-(2,4-Dinitrophenyl)-1H-Imidazol-4-Yl]-2-{[(9H-Fluoren-9-Ylmethoxy)Carbonyl]Amino}Propanoic acid is a sophisticated, non-natural amino acid derivative featuring a dinitrophenyl (DNP) protecting group and a fluorenylmethoxycarbonyl (Fmoc) protecting group on the α-amine. This compound is of critical importance in advanced peptide synthesis and chemical biology research, where it serves as a specialized building block. It is primarily needed by research institutions, pharmaceutical R&D departments, and fine chemical manufacturers developing novel peptide-based therapeutics, diagnostic tools, and biochemical probes.

Application

• Solid-Phase Peptide Synthesis (SPPS): As a protected amino acid precursor for the controlled incorporation of imidazole-containing side chains into custom peptide sequences.
• Chemical Biology Probes: Synthesis of labeled or modified peptides used to study protein-protein interactions, enzyme mechanisms, and cellular signaling pathways.
• Pharmaceutical Intermediate: A key raw material in the research and development stages of novel peptide drugs and drug candidates.
• Bioconjugation: Facilitating site-specific modifications of peptides and proteins for creating antibody-drug conjugates (ADCs) or diagnostic agents.
• Material Science Research: Exploration of novel bio-inspired polymers and peptide-based nanomaterials.
• Academic Research: Used in university and institutional labs for fundamental studies in organic chemistry, peptide chemistry, and medicinal chemistry.

Basic Information

Product Name	(2S)-3-[1-(2,4-Dinitrophenyl)-1H-Imidazol-4-Yl]-2-{[(9H-Fluoren-9-Ylmethoxy)Carbonyl]Amino}Propanoic Acid
CAS No.	83999-94-4
Molecular Formula	C27H21N5O7
Molecular Weight	527.49 g/mol
Synonyms	Fmoc-Dnp-His-OH; Fmoc-His(Dnp)-OH; Nα-Fmoc-Nim-Dnp-L-histidine; (2S)-2-[(9H-Fluoren-9-ylmethoxy)carbonylamino]-3-[1-(2,4-dinitrophenyl)imidazol-4-yl]propanoic acid; 1-(2,4-Dinitrophenyl)-Nα-Fmoc-L-histidine; Fmoc-L-Histidine(Dnp)-OH; Fmoc-3-(1-(2,4-dinitrophenyl)-1H-imidazol-4-yl)-L-alanine
EINECS	Contact for details

Quality Control

Our (2S)-3-[1-(2,4-Dinitrophenyl)-1H-Imidazol-4-Yl]-2-{[(9H-Fluoren-9-Ylmethoxy)Carbonyl]Amino}Propanoic acid is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC for purity and chiral analysis to confirm stereochemical integrity, ensuring compliance with research-grade specifications. A comprehensive Certificate of Analysis (COA) detailing identity, purity, and impurity profiles is provided with every shipment to guarantee batch-to-batch consistency and traceability.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 15-25°C. This compound is hygroscopic (moisture-sensitive); therefore, containers must be kept tightly sealed in a desiccated environment to prevent degradation. For long-term storage, consider storing under an inert atmosphere.

Specification

Item	Specification
Appearance	Yellow to orange powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Purity (HPLC)	≥ 95.0%
Specific Rotation	Contact for details
Water Content (KF)	≤ 2.0%
Heavy Metals	≤ 20 ppm
Residual Solvents (GC)	Complies with ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.