Description

Captopril-D7 is a deuterium-labeled analog of the widely used antihypertensive drug, Captopril, where seven hydrogen atoms are replaced with deuterium. This stable isotope-labeled compound is essential for use as an internal standard in quantitative bioanalytical methods, ensuring the highest accuracy and reliability in pharmacokinetic and metabolic studies. It is a critical tool for pharmaceutical R&D laboratories, contract research organizations (CROs), and academic institutions engaged in advanced drug development and analysis.

Application

• Internal Standard for LC-MS/MS: Primary application as a high-purity internal standard in Liquid Chromatography-Tandem Mass Spectrometry (LC-MS/MS) for the precise quantification of Captopril in biological matrices like plasma, serum, and urine.
• Drug Metabolism and Pharmacokinetics (DMPK): Enables accurate tracking of drug absorption, distribution, metabolism, and excretion (ADME) profiles in preclinical and clinical studies.
• Bioequivalence Studies: Critical for ensuring analytical method validity in studies comparing generic and brand-name formulations of Captopril.
• Pharmaceutical Quality Control: Used in advanced analytical methods to monitor drug substance and product purity and stability.
• Isotope Dilution Mass Spectrometry (IDMS): Serves as the ideal spike for this highly accurate technique in reference material characterization and clinical assay development.
• Academic and Clinical Research: Supports investigative research into hypertension, heart failure, and the metabolic pathways of ACE inhibitors.

Basic Information

Product Name	Captopril-D7
CAS No.	83993-06-0
Molecular Formula	C9H8D7NO3S
Molecular Weight	220.32 g/mol (approx.)
Synonyms	(2S)-1-[(2S)-3-Mercapto-2-methylpropanoyl]-L-proline-d7; 1-[(2S)-3-Mercapto-2-methyl-1-oxopropyl]-L-proline-d7; SQ 14,225-d7; L-Proline, 1-[(2S)-3-mercapto-2-methyl-1-oxopropyl]-, d7-; Deuterated Captopril (D7); Captopril-d7; [D7]-Captopril
EINECS	Contact for details

Quality Control

Every batch of Captopril-D7 is manufactured and analyzed under strict quality management systems. We guarantee high chemical and isotopic purity, verified by advanced spectroscopic and chromatographic techniques including NMR, HPLC, and MS. A comprehensive Certificate of Analysis (COA) detailing purity, isotopic enrichment, and all analytical results is provided with each shipment to ensure traceability and compliance with your research and regulatory requirements.

Storage

Preserve in a tightly closed container, protected from light. Store at controlled room temperature (15-25°C) or as indicated on the label. This product is hygroscopic (moisture-sensitive). Keep the container tightly sealed in a dry environment to prevent degradation.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Isotopic Purity (MS)	≥ 98.0 atom % D
Chemical Purity	≥ 95.0%
Residual Solvents (GC)	Complies with ICH guidelines
Water Content (KF)	≤ 1.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.