Description

8-Chloro-2-Fluoro-6-(1-Methyl-4-Piperidyl)-6H-Dibenz(B,E)-1,4-Oxathiep In Hydrogen Maleate is a high-purity, non-racemic organic compound primarily utilized as a critical pharmaceutical intermediate. Its complex heterocyclic structure, featuring a dibenzoxathiepine core with chloro, fluoro, and piperidyl substituents, makes it a valuable building block for advanced medicinal chemistry research and development. This compound is essential for researchers and manufacturers in the pharmaceutical industry focused on synthesizing novel therapeutic agents, particularly in central nervous system (CNS) and receptor-targeted drug discovery programs.

Application

• Pharmaceutical Intermediate: Key synthetic precursor in the development of novel active pharmaceutical ingredients (APIs).
• Medicinal Chemistry Research: Used in structure-activity relationship (SAR) studies and lead optimization for new drug candidates.
• CNS Drug Discovery: Serves as a scaffold for compounds targeting neurological and psychiatric disorders.
• Receptor Ligand Synthesis: Building block for creating selective ligands for various G-protein-coupled receptors (GPCRs).
• Process Chemistry & Scale-Up: Employed in route scouting and optimization for commercial-scale API manufacturing.
• Reference Standard: Used as an analytical standard for quality control and method validation in pharmaceutical analysis.

Basic Information

Product Name	8-Chloro-2-Fluoro-6-(1-Methyl-4-Piperidyl)-6H-Dibenz(B,E)-1,4-Oxathiep In Hydrogen Maleate
CAS No.	83986-24-7
Molecular Formula	C21H21ClFNO3S
Molecular Weight	421.91 g/mol
Synonyms	8-Chloro-2-fluoro-6-(1-methyl-4-piperidyl)-6H-dibenz[b,e][1,4]oxathiepin hydrogen maleate; 6H-Dibenz[b,e][1,4]oxathiepin, 8-chloro-2-fluoro-6-(1-methyl-4-piperidinyl)-, (Z)-2-butenedioate (1:1); 83986-24-7; 8-Chloro-2-fluoro-6-(1-methylpiperidin-4-yl)-6H-dibenzo[b,e][1,4]oxathiepin maleate; DBFOX Maleate Salt; Contact for additional synonyms.
EINECS	Contact for details

Quality Control

Our 8-Chloro-2-Fluoro-6-(1-Methyl-4-Piperidyl)-6H-Dibenz(B,E)-1,4-Oxathiep In Hydrogen Maleate is manufactured under strict quality management systems. Every batch undergoes comprehensive analytical testing, including HPLC for purity, chiral analysis to confirm stereochemical integrity, and identity confirmation via spectroscopic methods. We provide Certificates of Analysis (COA) with each shipment, detailing batch-specific results. Our quality commitment ensures material suitable for advanced research and development applications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This compound is hygroscopic (moisture-sensitive) and light-sensitive; containers must be kept sealed under an inert atmosphere (e.g., nitrogen or argon) after opening to prevent degradation. Keep away from incompatible materials.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Purity (HPLC)	≥ 98.0%
Chiral Purity	≥ 99.0% ee
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.