Description

H-Pro-His-Gly-Oh CAS NO 83960-30-9 is a synthetic tripeptide derivative, specifically a histidine-containing peptide, with the sequence Proline-Histidine-Glycine. This compound is of significant interest in biochemical research and pharmaceutical development due to its role as a potential intermediate or building block for more complex peptides and peptidomimetics. It is primarily utilized by research institutions, pharmaceutical R&D departments, and fine chemical manufacturers engaged in peptide synthesis, enzyme substrate studies, and the exploration of novel bioactive compounds.

Application

• Pharmaceutical Research & Development: Serves as a key intermediate in the synthesis of novel peptide-based drug candidates and active pharmaceutical ingredients (APIs).
• Biochemical Research: Used as a substrate or standard in enzymatic studies, particularly those involving histidine-related pathways or metalloenzymes.
• Peptide Library Construction: Acts as a building block in combinatorial chemistry for creating diverse peptide libraries for screening purposes.
• Academic Studies: Employed in universities and research labs for investigating peptide structure, function, and stability.
• Fine Chemical Synthesis: Utilized as a specialized intermediate for the custom synthesis of more complex organic molecules and peptidomimetics.

Basic Information

Product Name	H-Pro-His-Gly-Oh
CAS No.	83960-30-9
Molecular Formula	C14H20N6O4
Molecular Weight	336.35 g/mol
Synonyms	L-Prolyl-L-histidylglycine; Pro-His-Gly-OH; H-Pro-His-Gly-OH tripeptide; L-Pro-L-His-Gly; Proline-Histidine-Glycine; PHG; 83960-30-9; (S)-2-((S)-1-((S)-2-Amino-1-hydroxyethyl)-1H-imidazol-4-yl)-5-(pyrrolidin-2-yl)pentanoic acid (IUPAC-like)
EINECS	Contact for details

Quality Control

Our H-Pro-His-Gly-Oh is produced under strict quality management protocols. Each batch undergoes rigorous analytical testing, including HPLC for purity assessment and identity confirmation via mass spectrometry (MS) and infrared spectroscopy (IR), to ensure it meets high-purity research-grade standards. Certificates of Analysis (COA) with detailed chromatographic data are available upon request to support your quality assurance processes.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (typically 15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed in a dry environment to prevent absorption of moisture. For long-term storage, consider desiccants or inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (HPLC/MS)	Conforms
Purity (HPLC)	≥ 95.0%
Water Content (KF)	≤ 5.0%
Heavy Metals	< 20 ppm
Residual Solvents (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.