Description

Fasudil Impurity 21 is a specified impurity of the pharmaceutical agent Fasudil, a Rho-kinase inhibitor. This compound is critical for pharmaceutical research and development, serving as a key reference standard in the analytical characterization and quality control of Fasudil drug substances and products. It is essential for scientists and quality assurance professionals in the pharmaceutical and biotechnology industries who require high-purity chemical standards to ensure product safety, efficacy, and regulatory compliance.

Application

• Primary use as a certified reference standard (CRS) for the analytical testing of Fasudil API.
• Critical component in method development and validation for HPLC, UPLC, and GC assays.
• Used in stability studies and impurity profiling to monitor degradation pathways.
• Essential for pharmacopoeial testing to meet regulatory requirements (e.g., ICH guidelines).
• Supports research on Rho-kinase inhibitors and related cardiovascular therapeutics.
• Employed in quality control laboratories for batch release testing of pharmaceutical products.

Basic Information

Product Name	Fasudil Impurity 21
CAS No.	83848-55-9
Molecular Formula	C14H17N3O2S
Molecular Weight	291.37 g/mol
Synonyms	5-(1,4-Diazepan-1-ylsulfonyl)isoquinoline; 1-(5-Isoquinolinesulfonyl)homopiperazine; HA-1100; HA 1100; HA1100; Fasudil Related Compound 21; 1-(Isoquinoline-5-sulfonyl)homopiperazine; 1-Homopiperazinyl-5-isoquinolinesulfonamide
EINECS	Contact for details

Quality Control

Every batch of Fasudil Impurity 21 is manufactured and tested under strict quality management systems. Our products undergo rigorous analytical testing, including HPLC purity analysis and spectroscopic identification (IR, NMR, MS), to ensure compliance with high-purity reference standard requirements. A comprehensive Certificate of Analysis (COA) detailing identity, purity, and impurity profile is provided with each shipment and is available upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at controlled room temperature (15-25°C). This material is hygroscopic (moisture-sensitive) and should be handled in a dry environment to prevent degradation.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference
Purity (HPLC)	≥ 98.0%
Related Substances (HPLC)	Individual impurity: ≤ 0.5% Total impurities: ≤ 2.0%
Residual Solvents (GC)	Complies with ICH limits
Water Content (KF)	≤ 1.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.