Description

n-Fmoc-N'-Tosyl-L-Arginine is a protected derivative of the essential amino acid L-arginine, specifically engineered for solid-phase peptide synthesis (SPPS). This compound is critical for researchers and manufacturers requiring high-purity, sequence-specific peptide building blocks with orthogonal protecting group strategies. It is primarily utilized by pharmaceutical R&D teams, biotechnology companies, and fine chemical suppliers engaged in the development of therapeutic peptides, diagnostic agents, and biochemical tools.

Application

• Solid-Phase Peptide Synthesis (SPPS): Serves as a key Fmoc-protected arginine derivative, where the tosyl (Tos) group protects the guanidino side chain, enabling controlled elongation of complex peptide sequences.
• Therapeutic Peptide Development: Used in the research and production of peptide-based pharmaceuticals targeting cardiovascular diseases, metabolic disorders, and cancer.
• Bioconjugation and Labeling: Acts as a precursor for introducing arginine residues into peptides designed for conjugation with dyes, drugs, or other functional molecules.
• Biochemical Research: Employed in studies of protein-protein interactions, enzyme substrates, and receptor ligands where specific arginine incorporation is required.
• Custom Peptide Service Providers: A fundamental raw material for CROs and CDMOs offering bespoke peptide synthesis services to academic and industrial clients.

Basic Information

Product Name	n-Fmoc-N'-Tosyl-L-Arginine
CAS No.	83792-47-6
Molecular Formula	C29H31N5O6S
Molecular Weight	577.65 g/mol
Synonyms	Fmoc-Arg(Tos)-OH; N-α-Fmoc-N-ω-tosyl-L-arginine; Fmoc-L-arginine(Tos)-OH; (S)-2-((((9H-Fluoren-9-yl)methoxy)carbonyl)amino)-5-((4-methylphenyl)sulfonamido)pentanoic acid; Fmoc-Arg(Tos); Nα-Fmoc-Nω-tosyl-L-arginine; L-Arginine, N2-[(9H-fluoren-9-ylmethoxy)carbonyl]-N5-[(4-methylphenyl)sulfonyl]-
EINECS	Contact for details

Quality Control

Our n-Fmoc-N'-Tosyl-L-Arginine is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity, chiral analysis to confirm enantiomeric integrity, and identity confirmation via IR and NMR spectroscopy. Certificates of Analysis (COA) detailing all specifications are provided with every shipment to ensure traceability and compliance with research and cGMP-grade requirements.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 2-8°C. This material is hygroscopic (moisture-sensitive) and should be handled under anhydrous conditions to maintain stability and purity. Allow the sealed container to equilibrate to room temperature before opening to prevent moisture condensation.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Conforms to reference
Assay (HPLC)	≥98.0%
Optical Rotation	[α]²⁰D: -10.0° to -12.0° (c=1 in DMF)
Water Content (KF)	≤1.0%
Heavy Metals	≤20 ppm
Residual Solvents (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.