Description

S-(-)-Norketamine CAS NO 83777-65-5 is the S-enantiomer of norketamine, a primary active metabolite of the dissociative anesthetic ketamine. This high-purity chiral intermediate is critical for advanced pharmaceutical research and development, particularly in the study of neuropharmacology and the synthesis of novel therapeutic agents. It is essential for researchers and manufacturers in the pharmaceutical, biotechnology, and fine chemical sectors requiring precise stereochemistry for their processes.

Application

• Pharmaceutical Reference Standard: Used as a certified standard for analytical method development, validation, and quality control in drug testing and forensic analysis.
• Active Pharmaceutical Ingredient (API) Intermediate: A key chiral building block in the research and synthesis of next-generation antidepressant and neuroactive compounds.
• Metabolite Studies: Critical for in-vitro and in-vivo pharmacokinetic and metabolic pathway studies related to ketamine and its analogs.
• Neuroscience Research: Employed in preclinical research to investigate NMDA receptor mechanisms, neuroplasticity, and potential treatments for depression and chronic pain.
• Process Development & Scale-up: Serves as a starting material or intermediate for process chemistry teams developing scalable synthetic routes for specialized APIs.
• Analytical Chemistry: Utilized in chromatography (HPLC, GC) as a high-purity standard for calibrating instruments and quantifying samples.

Basic Information

Product Name	S-(-)-Norketamine
CAS No.	83777-65-5
Molecular Formula	C12H14ClNO
Molecular Weight	223.70 g/mol
Synonyms	(S)-Norketamine; (2S)-2-(2-Chlorophenyl)-2-(methylamino)cyclohexan-1-one; S-Norketamine; (-)-Norketamine; (S)-(-)-Norketamine; Norketamine S-(-)-enantiomer; Desmethylketamine (S-enantiomer); CL-88 (S-enantiomer)
EINECS	Contact for details

Quality Control

Our S-(-)-Norketamine is manufactured under strict quality management systems to ensure batch-to-batch consistency and high purity. Each lot undergoes comprehensive analytical testing, including chiral purity verification by HPLC, to meet the exacting standards required for research and development. A Certificate of Analysis (COA) detailing identity, purity, and impurity profiles is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and must be kept under inert conditions if the container is opened repeatedly.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to reference spectrum
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥98.0%
Chiral Purity (HPLC)	≥99.0% (S-enantiomer)
Related Substances (HPLC)	Total impurities ≤2.0%
Residual Solvents (GC)	Complies with ICH guidelines
Loss on Drying	≤1.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.