Description

R-(+)-Norketamine is a key chiral intermediate and metabolite of the anesthetic ketamine, distinguished by its specific (R)-(+) enantiomeric form. This high-purity compound is essential for advanced pharmaceutical research and development, particularly in the study of neuropharmacology and the synthesis of novel therapeutic agents. It is primarily utilized by research institutions, pharmaceutical developers, and analytical laboratories focused on central nervous system (CNS) drug discovery and metabolite reference standards.

Application

• Pharmaceutical Reference Standard: Serves as a certified metabolite standard for pharmacokinetic and bioanalytical studies of ketamine.
• Neuropharmacology Research: Used in preclinical research to investigate the mechanisms of action, metabolism, and neurobiological effects of ketamine and its analogs.
• Active Pharmaceutical Ingredient (API) Intermediate: A critical chiral building block in the synthetic pathway for developing new CNS-targeting pharmaceuticals.
• Metabolite Identification & Profiling: Essential for drug metabolism and disposition (DMPK) studies to identify and quantify metabolic pathways.
• Analytical Chemistry: Employed as a high-purity calibrant in methods development for techniques like HPLC, LC-MS, and GC-MS.
• Forensic & Clinical Toxicology: Used as a reference material for the accurate detection and quantification of ketamine metabolites in forensic and clinical samples.

Basic Information

Product Name	R-(+)-Norketamine
CAS No.	83777-64-4
Molecular Formula	C12H14ClNO
Molecular Weight	223.70 g/mol
Synonyms	(R)-2-(2-Chlorophenyl)-2-(methylamino)cyclohexanone; (R)-Norketamine; (+)-Norketamine; (R)-(+)-2-Amino-2-(2-chlorophenyl)cyclohexanone; Desmethylketamine (R-enantiomer); Nor-Ketamine (R-form); CL-88 Metabolite (R+)
EINECS	Contact for details

Quality Control

Our R-(+)-Norketamine is manufactured under strict quality management systems to ensure batch-to-batch consistency and high purity, suitable for sensitive research applications. Each lot is accompanied by a comprehensive Certificate of Analysis (COA) detailing identity, purity (typically ≥98% by HPLC), chiral purity, and impurity profiles. We support compliance with relevant research and development standards.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at controlled room temperature (15-25°C). The product is light-sensitive and should be handled under appropriate conditions to maintain stability.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to reference spectrum
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥ 98.0%
Chiral Purity (Chiral HPLC)	≥ 99.0% (R-enantiomer)
Related Substances (HPLC)	Total impurities ≤ 2.0% Any single unknown impurity ≤ 0.5%
Residual Solvents (GC)	Complies with ICH guidelines
Loss on Drying	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.